FN Archimer Export Format
PT J
TI Transgenerational exposure to ocean acidification impacts the hepatic transcriptome of European sea bass (Dicentrarchus labrax)
BT 
AF AUFFRET, Pauline
   Servili, Arianna
   Gonzalez, Anne-Alicia
   Fleury, Marie-Lou
   Mark, Felix Christopher
   Mazurais, David
AS 1:1;2:2;3:3;4:2;5:4;6:2;
FF 1:PDG-IRSI-SEBIMER;2:PDG-RBE-PHYTNESS;3:;4:PDG-RBE-PHYTNESS;5:;6:PDG-RBE-PHYTNESS;
C1 IFREMER, SEBIMER, Plouzané, 29280, France
   IFREMER, PHYTNESS, Univ Brest, CNRS, IRD, LEMAR, Plouzané, 29280, France
   MGX-Montpellier GenomiX, Univ. Montpellier, CNRS, INSERM, Montpellier, France
   Department of Integrative Ecophysiology, Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research (AWI), 27570, Bremerhaven, Germany
C2 IFREMER, FRANCE
   IFREMER, FRANCE
   UNIV MONTPELLIER, FRANCE
   INST A WEGENER, GERMANY
SI BREST
SE PDG-IRSI-SEBIMER
   PDG-RBE-PHYTNESS
UM LEMAR
IN WOS Ifremer UPR
   WOS Ifremer UMR
   DOAJ
   copubli-france
   copubli-europe
   copubli-univ-france
IF 4.4
TC 0
UR https://archimer.ifremer.fr/doc/00842/95388/103157.pdf
   https://archimer.ifremer.fr/doc/00842/95388/103158.xlsx
   https://archimer.ifremer.fr/doc/00842/95388/103159.xlsx
   https://archimer.ifremer.fr/doc/00842/95388/103160.xlsx
   https://archimer.ifremer.fr/doc/00842/95388/103161.xlsx
LA English
DT Article
AB Physiological effects of ocean acidification associated with elevated CO2 concentrations in seawater is the subject of numerous studies in teleost fish. While the short time within-generation impact of ocean acidification (OA) on acid-base exchange and energy metabolism is relatively well described, the effects associated with transgenerational exposure to OA are much less known. Yet, the impacts of OA can vary in time with the potential for acclimation or adaptation of a species. Previous studies in our lab demonstrated that transgenerational exposure to OA had extensive effects on the transcriptome of the olfactory epithelium of European sea bass (Dicentrarchus labrax), especially on genes related to ion balance, energy metabolism, immune system, synaptic plasticity, neuron excitability and wiring. In the present study, we complete the previous work by investigating the effect of transgenerational exposure to OA on the hepatic transcriptome of European sea bass. Differential gene expression analysis was performed by RNAseq technology on RNA extracted from the liver of two groups of 18 months F2 juveniles that had been exposed since spawning to the same AO conditions as their parents (F1) to either actual pH or end-of-century predicted pH levels (IPCC RCP8.5), respectively. Here we show that transgenerational exposure to OA significantly impacts the expression of 236 hepatic transcripts including genes mainly involved in inflammatory/immune responses but also in carbohydrate metabolism and cellular homeostasis. Even if this transcriptomic impact is relatively limited compared to what was shown in the olfactory system, this work confirmed that fish transgenerationally exposed to OA exhibit molecular regulation of processes related to metabolism and inflammation. Also, our data expand the up-regulation of a key gene involved in different physiological pathways including calcium homeostasis (i.e. pthr1), which we already observed in the olfactory epithelium, to the liver. Even if our experimental design does not allow to discriminate direct within F2 generation effects from transgenerational plasticity, these results offer the perspective of more functional analyses to determine the potential physiological impact of OA exposure on fish physiology with ecological relevance. 
PY 2023
PD JUL
SO Bmc Genomics
SN 1471-2164
PU Springer Science and Business Media LLC
VL 24
IS 1
UT 001011460800003
DI 10.1186/s12864-023-09353-x
ID 95388
ER

EF