FN Archimer Export Format
PT J
TI Testing for parallel genomic and epigenomic footprints of adaptation to urban life in a passerine bird
BT 
AF Caizergues, Aude E.
   LE LUYER, Jeremy
   Grégoire, Arnaud
   Szulkin, Marta
   Senar, Juan-Carlos
   Charmantier, Anne
   Perrier, Charles
AS 1:1;2:2;3:1;4:3;5:4;6:1;7:5;
FF 1:;2:;3:;4:;5:;6:;7:;
C1 CEFE, Univ Montpellier, CNRS, Univ Paul Valéry Montpellier 3, EPHE, IRD, Montpellier, France
   Ifremer, UMR EIO 241, Centre du Pacifique, Taravao, Tahiti, Polynésie française, France
   Centre of New Technologies, University of Warsaw, S. Banacha 2c, 02-097 Warsaw, Poland
   Museu de Ciències Naturals de Barcelona, Parc Ciutadella, 08003 Barcelona, Spain
   CBGP, INRAe, CIRAD, IRD, Montpellier SupAgro, Univ. Montpellier, Montpellier, France
C2 UNIV MONTPELLIER, FRANCE
   IFREMER, FRANCE
   UNIV WARSAW, POLAND
   MUSEU CIENCIES NATURALS BARCELONA, SPAIN
   INRAE, FRANCE
UM EIO
TC 0
UR https://archimer.ifremer.fr/doc/00847/95934/103881.pdf
LA English
DT Article
DE ;adaptation;DNA methylation;epigenomics;genomics;urbanization
AB Identifying the molecular mechanisms involved in rapid adaptation to novel environments and determining their predictability are central questions in Evolutionary Biology and pressing issues due to rapid global changes. Complementary to genetic responses to selection, faster epigenetic variations such as modifications of DNA methylation may play a substantial role in rapid adaptation. In the context of rampant urbanization, joint examinations of genomic and epigenomic mechanisms are still lacking. Here, we investigated genomic (SNP) and epigenomic (CpG methylation) responses to urban life in a passerine bird, the Great tit (Parus major). To test whether urban evolution is predictable (i.eparallel) or involves mostly non-parallel molecular processes among cities, we analysed three distinct pairs of city and forest Great tit populations across Europe. Results reveal a polygenic response to urban life, with both many genes putatively under weak divergent selection and multiple differentially methylated regions (DMRs) between forest and city great tits. DMRs mainly overlapped transcription start sites and promotor regions, suggesting their importance in the modulation gene expression. Both genomic and epigenomic outliers were found in genomic regions enriched for genes with biological functions related to nervous system, immunity, behaviour, hormonal and stress responses. Interestingly, comparisons across the three pairs of city-forest populations suggested little parallelism in both genetic and epigenetic responses. Our results confirm, at both the genetic and epigenetic levels, hypotheses of polygenic and largely non-parallel mechanisms of rapid adaptation in new environments such as urbanized areas. 
PY 2021
PD FEB
SO bioRxiv
PU Cold Spring Harbor Laboratory
DI 10.1101/2021.02.10.430452
ID 95934
ER

EF