FN Archimer Export Format
PT J
TI Epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to Pacific oyster mortality syndrome
BT 
AF Gawra, Janan
   VALDIVIESO MUNOZ, Alejandro
   Roux, Fabrice
   Laporte, Martin
   de Lorgeril, Julien
   Gueguen, Yannick
   Saccas, Mathilde
   Escoubas, Jean-Michel
   Montagnani, Caroline
   DESTOUMIEUX GARZON, Delphine
   Lagarde, Franck
   Leroy, Marc A.
   Haffner, Philippe
   Petton, Bruno
   Cosseau, Céline
   Morga, Benjamin
   Dégremont, Lionel
   Mitta, Guillaume
   Grunau, Christoph
   Vidal-Dupiol, Jeremie
AS 1:1;2:10;3:3;4:4;5:2,5;6:2,6;7:2;8:10;9:2;10:10;11:6;12:10;13:2;14:7;15:1;16:8;17:8;18:1,9;19:1;20:2;
FF 1:;2:;3:;4:;5:PDG-RBE-LEADNC;6:PDG-ODE-LITTORAL-LERLR;7:PDG-RBE-IHPE;8:;9:PDG-RBE-IHPE;10:;11:PDG-ODE-LITTORAL-LERLR;12:;13:PDG-RBE-IHPE;14:PDG-RBE-PHYTNESS;15:;16:PDG-RBE-ASIM;17:PDG-RBE-ASIM;18:PDG-RBE-RMPF;19:;20:PDG-RBE-IHPE;
C1 IHPE, Université de Perpignan Via Domitia, CNRS, Ifremer, Université de Montpellier, Perpignan, France.
   IHPE, Université de Montpellier, CNRS, Ifremer, Université de Perpignan Via Domitia, Montpellier, France.
   LIPME, INRAE, CNRS, Université de Toulouse, Castanet-Tolosan, France.
   Division de l'expertise sur la faune Aquatique, Ministère des Forêts, de la Faune et des Parcs (MFFP), 880 chemin Sainte-Foy, G1S 4X4 Québec, Québec, Canada.
   Ifremer, IRD, Université de la Nouvelle-Calédonie, Université de La Réunion, ENTROPIE, Nouméa, Nouvelle-Calédonie, France.
   MARBEC, Université de Montpellier, CNRS, Ifremer, IRD, Sète, France.
   Université de Brest, Ifremer, CNRS, IRD, LEMAR, F-29280 Plouzané, France.
   Ifremer, ASIM, Adaptation Santé des Invertébrés Marins, La Tremblade, France.
   Université de la Polynésie Française, ILM, IRD, Ifremer, F-98719 Tahiti, French Polynesia, France.
   IHPE, Université de Montpellier, CNRS, Ifremer, Université de Perpignan Via Domitia, Montpellier, France.
C2 UNIV PERPIGNAN, FRANCE
   IFREMER, FRANCE
   UNIV TOULOUSE, FRANCE
   MINIST FORETS FAUNE PARCS QUEBEC MFFP, CANADA
   IFREMER, FRANCE
   IFREMER, FRANCE
   IFREMER, FRANCE
   IFREMER, FRANCE
   IFREMER, FRANCE
   CNRS, FRANCE
SI SAINT VINCENT
   SETE
   MONTPELLIER
   BREST
   LA TREMBLADE
   TAHITI
SE PDG-RBE-LEADNC
   PDG-ODE-LITTORAL-LERLR
   PDG-RBE-IHPE
   PDG-RBE-PHYTNESS
   PDG-RBE-ASIM
   PDG-RBE-RMPF
UM LEMAR
   MARBEC
   IHPE
   EIO
   ENTROPIE
IN WOS Ifremer UPR
   WOS Ifremer UMR
   WOS Cotutelle UMR
   DOAJ
   copubli-france
   copubli-univ-france
   copubli-int-hors-europe
IF 13.6
TC 4
UR https://archimer.ifremer.fr/doc/00853/96450/104749.pdf
   https://archimer.ifremer.fr/doc/00853/96450/104750.pdf
   https://archimer.ifremer.fr/doc/00853/96450/104751.zip
   https://archimer.ifremer.fr/doc/00853/96450/104752.zip
   https://archimer.ifremer.fr/doc/00853/96450/104932.pdf
LA English
DT Article
AB Disease emergence is accelerating with global changes. Understanding by which mechanisms host populations can rapidly adapt will be crucial for management practices. Pacific oyster mortality syndrome (POMS) imposes a substantial and recurrent selective pressure on oyster populations, and rapid adaptation may arise through genetics and epigenetics. In this study, we used (epi)genome-wide association mapping to show that oysters differentially exposed to POMS displayed genetic and epigenetic signatures of selection. Consistent with higher resistance to POMS, the genes targeted included many genes in several pathways related to immunity. By combining correlation, DNA methylation quantitative trait loci, and variance partitioning, we revealed that a third of phenotypic variation was explained by interactions between the genetic and epigenetic information, ~14% by the genome, and up to 25% by the epigenome alone. Similar to genetically based adaptation, epigenetic mechanisms notably governing immune responses can contribute substantially to the rapid adaptation of hosts to emerging infectious diseases. 
PY 2023
PD SEP
SO Science Advances
SN 2375-2548
PU American Association for the Advancement of Science (AAAS)
VL 9
IS 36
UT 001129563900011
DI 10.1126/sciadv.adh8990
ID 96450
ER

EF