FN Archimer Export Format
PT J
TI Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians
BT 
AF Burioli, E. A. V.
   Hammel, M.
   Vignal, Emmanuel
   Vidal-Dupiol, Jeremie
   Mitta, Guillaume
   Thomas, FREDERIC
   Bierne, N.
   Destoumieux-Garzón, Delphine
   Charrière, G. M.
AS 1:5;2:2,5;3:5;4:1;5:3;6:4;7:2;8:6;9:5;
FF 1:;2:;3:;4:PDG-RBE-IHPE;5:PDG-RBE-RMPF;6:;7:;8:;9:;
C1 IHPE, Univ Montpellier, CNRS, IFREMER, Univ Perpignan Via Domitia, Montpellier, France
   ISEM, Univ Montpellier, CNRS, EPHE, IRD, Montpellier, France
   IFREMER, UMR 241 Écosystèmes Insulaires Océaniens, Labex Corail, Centre Ifremer du Pacifique, Tahiti, Polynésie française
   CREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224-CNRS 5290-Université de Montpellier, Montpellier, France
   IHPE, Univ Montpellier, CNRS, IFREMER, Univ Perpignan Via Domitia, Montpellier, France
   IHPE, Univ Montpellier, CNRS, IFREMER, Univ Perpignan Via Domitia, Montpellier, France
C2 IFREMER, FRANCE
   CNRS, FRANCE
   IFREMER, FRANCE
   UNIV MONTPELLIER, FRANCE
   UNIV MONTPELLIER, FRANCE
   CNRS, FRANCE
SI MONTPELLIER
   TAHITI
SE PDG-RBE-IHPE
   PDG-RBE-RMPF
UM IHPE
   EIO
IN WOS Ifremer UMR
   WOS Cotutelle UMR
   DOAJ
   copubli-france
   copubli-univ-france
IF 5.8
TC 0
UR https://archimer.ifremer.fr/doc/00857/96883/105507.pdf
   https://archimer.ifremer.fr/doc/00857/96883/105508.zip
   https://archimer.ifremer.fr/doc/00857/96883/105558.pdf
LA English
DT Article
DE ;transmissible cancer;mussel;transcriptomics;oncogenic pathways;MtrBTN2;Mytilus
AB Transmissible cancer cell lines are rare biological entities giving rise to diseases at the crossroads of cancer and parasitic diseases. These malignant cells have acquired the amazing capacity to spread from host to host. They have been described only in dogs, Tasmanian devils and marine bivalves. The Mytilus trossulus bivalve transmissible neoplasia 2 (MtrBTN2) lineage has even acquired the capacity to spread inter-specifically between marine mussels of the Mytilus edulis complex worldwide. To identify the oncogenic processes underpinning the biology of these atypical cancers we performed transcriptomics of MtrBTN2 cells. Differential expression, enrichment, protein–protein interaction network, and targeted analyses were used. Overall, our results suggest the accumulation of multiple cancerous traits that may be linked to the long-term evolution of MtrBTN2. We also highlight that vertebrate and lophotrochozoan cancers could share a large panel of common drivers, which supports the hypothesis of an ancient origin of oncogenic processes in bilaterians. 
PY 2023
PD OCT
SO Open Biology
SN 2046-2441
PU The Royal Society
VL 13
IS 10
UT 001185579700001
DI 10.1098/rsob.230259
ID 96883
ER

EF