FN Archimer Export Format
PT J
TI Gamma irradiation-induced offspring masculinization is associated with epigenetic changes in female zebrafish
BT 
AF Guirandy, Noëmie
   Simon, Olivier
   Geffroy, Benjamin
   Daffe, Guillemine
   Daramy, Flore
   Houdelet, Camille
   Gonzalez, Patrice
   Pierron, Fabien
AS 1:1;2:1;3:2;4:3;5:3;6:2;7:3;8:3;
FF 1:;2:;3:PDG-RBE-MARBEC-LAAAS;4:;5:;6:PDG-RBE-MARBEC-LAAAS;7:;8:;
C1 IRSN/PSE-ENV/SRTE/LECO, Centre de Cadarache-B.P. 3 – Bat 183, 13115 St Paul Lez Durance, France
   MARBEC, Univ Montpellier, CNRS, Ifremer, IRD, Montpellier, France
   Univ. Bordeaux, CNRS, Bordeaux INP, EPOC, UMR 5805, F-33600 Pessac, France
C2 IRSN, FRANCE
   IFREMER, FRANCE
   UNIV BORDEAUX, FRANCE
SI PALAVAS
SE PDG-RBE-MARBEC-LAAAS
UM MARBEC
IN WOS Ifremer UMR
   DOAJ
   copubli-france
   copubli-univ-france
IF 6.8
TC 0
UR https://archimer.ifremer.fr/doc/00867/97929/107046.pdf
   https://archimer.ifremer.fr/doc/00867/97929/107047.docx
LA English
DT Article
DE ;Sex differentiation;Methylation;Cortisol;Zebrafish;Irradiation;Multigenerational
AB Sex ratio variation is a key topic in ecology, because of its direct effects on population dynamics and thus, on animal conservation strategies. Among factors affecting sex ratio, types of sex determination systems have a central role, since some species could have a sex determined by genetic factors, environmental factors or a mix of those two. Yet, most studies on the factors affecting sex determination have focused on temperature or endocrine-disrupting chemicals (EDCs), and much less is known regarding other factors. Exposure to gamma irradiation was found to trigger offspring masculinization in zebrafish. Here we aimed at deciphering the potential mechanisms involved, by focusing on stress (i.e. cortisol) and epigenetic regulation of key genes involved in sex differentiation in fish. Cortisol levels in exposed and control (F0) zebrafish females’ gonads were similar. However, irradiation increased the DNA methylation level of foxl2a and cyp19a1a in females of the F0 and F1 generation, respectively, while no effects were detected in testis. Overall, our results suggest that parental exposure could alter offspring sex ratio, at least in part by inducing methylation changes in ovaries. 
PY 2024
PD JAN
SO Ecotoxicology And Environmental Safety
SN 0147-6513
PU Elsevier BV
VL 269
UT 001141474300001
DI 10.1016/j.ecoenv.2023.115790
ID 97929
ER

EF