FN Archimer Export Format
PT J
TI Structuring effects of archaeal replication origins
BT 
AF Mottez, Clémence
   Puech, Romain
   Flament, Didier
   Myllykallio, Hannu
AS 1:1;2:1;3:2;4:1;
FF 1:;2:;3:PDG-REM-BEEP-LMEE;4:;
C1 Laboratoire d’Optique et Biosciences (CNRS UMR7645, INSERM U1182), Ecole Polytechnique, Institut polytechnique de Paris, F-91128, Palaiseau, France
   Laboratoire de Microbiologie des Environnements Extrêmes (PDG-REM-BEEP-LMEE), IFREMER, Centre Bretagne, F-29280, Plouzané, France
C2 INST POLYTECH PARIS, FRANCE
   IFREMER, FRANCE
SI BREST
SE PDG-REM-BEEP-LMEE
TC 0
UR https://archimer.ifremer.fr/doc/00873/98479/107939.pdf
LA English
DT Article
AB Archaea use eukaryotic-like DNA replication proteins to duplicate circular chromosomes similar to those of bacteria. Although archaeal replication origins have been maintained during the evolution, they are non-essential under laboratory conditions. Here we propose the local deviations from Chargaff’s second parity rule of archaeal chromosomes result from the biased gene orientation and not from mutational biases. Our computational and experimental analyses indicate that the archaeal replication origins prevent head-to-head collisions of replication and transcription complexes as well as participate in coordination of the transfer of genetic information. Our results therefore suggest that the archaeal replication origins have alternative functions not related to their role in initiation of DNA replication. 
PY 2023
PD NOV
SO bioRxiv
PU Cold Spring Harbor Laboratory
DI 10.1101/2023.11.15.567178
ID 98479
ER

EF