FN Archimer Export Format
PT J
TI The genome of the simultaneously hermaphroditic snail Lymnaea stagnalis reveals an evolutionary expansion of FMRFamide-like receptors
BT 
AF Koene, Joris M.
   Jackson, Daniel J.
   Nakadera, Yumi
   Cerveau, Nicolas
   Madoui, Mohammed-Amin
   Noel, Benjamin
   Jamilloux, Véronique
   Poulain, Julie
   Labadie, Karine
   Silva, Corinne Da
   Davison, Angus
   Feng, Zhong-Ping
   Adema, Coen M.
   Klopp, Christophe
   Aury, Jean-Marc
   Wincker, Patrick
   Coutellec, Marie-Agnès
AS 1:1;2:2;3:1;4:2;5:3;6:4;7:5;8:4;9:6;10:4;11:7;12:8;13:9;14:10;15:4;16:4;17:11;
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C1 Amsterdam Institute for Life and Environment (A-LIFE), Vrije Universiteit, the netherlands
   Georg-August University of Göttingen, germany
   SEPIA, Institut François Jacob, Université Paris Saclay, france
   Génomique Métabolique, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay, france
   PROSE, INRAE, Paris-Saclay University, france
   Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay, france
   University of Nottingham, uk
   King's College, university of toronto, canada
   University of New Mexico, usa
   INRAE, Applied Mathematics and Informatics of Toulouse, MIAT UR875, france
   DECOD (Ecosystem Dynamics and Sustainability), INRAE, L’Institut Agro, france
C2 UNIV VRIJE AMSTERDAM, NETHERLANDS
   UNIV GOTTINGEN, GERMANY
   UNIV PARIS SACLAY, FRANCE
   UNIV PARIS SACLAY, FRANCE
   INRAE, FRANCE
   UNIV PARIS SACLAYOB, FRANCE
   UNIV NOTTINGHAM, UK
   UNIV TORONTO, CANADA
   UNIV NEW MEXICO, USA
   INRAE, FRANCE
   INRAE, FRANCE
UM DECOD
IN DOAJ
TC 0
UR https://archimer.ifremer.fr/doc/00879/99045/108827.pdf
   https://archimer.ifremer.fr/doc/00879/99045/108828.pdf
LA English
DT Article
DE ;Molluscan genome;nuclear receptors;GPCRs;gene expansion;simultaneous hermaphroditism
AB The great pond snail Lymnaea stagnalis has served as a model organism for over a century in diverse disciplines such as neurophysiology, evolution, ecotoxicology and developmental biology. To support both established uses and newly emerging research interests we have performed whole genome sequencing (~ 176 x depth), assembly and annotation of a single individual derived from an inbred line. These efforts resulted in a final assembly of 943 Mb (L50 = 257; N50 = 957,215) with a total of 22,499 predicted gene models. As a first step towards understanding the hermaphroditic reproductive biology of L. stagnalis, we identified molecular receptors, specifically nuclear receptors (including newly discovered 2xDNA binding domain-NRs), G protein-coupled receptors, and receptor tyrosine kinases, that may be involved in the cellular specification and maintenance of simultaneously active male and female reproductive systems. A phylogenetic analysis of one particular family of GPCRs (Rhodopsin neuropeptide FMRFamide-receptor-like genes) shows a remarkable expansion that coincides with the occurrence of simultaneous hermaphroditism in the Euthyneura gastropods. As some GPCRs and NRs also showed qualitative differences in expression in female (albumen gland) and male (prostate gland) organs, it is possible that separate regulation of male and female reproductive processes may in part have been enabled by an increased abundance of receptors in the transition from a separate-sexed state to a hermaphroditic condition. These findings will support efforts to pair receptors with their activating ligands, and more generally stimulate deeper insight into the mechanisms that underlie the modes of action of compounds involved in neuroendocrine regulation of reproduction, induced toxicity, and development in L. stagnalis, and molluscs in general. 
PY 2024
PD FEB
SO Under Review at Scientific Reports
PU Research Square Platform LLC
DI 10.21203/rs.3.rs-3948809/v1
ID 99045
ER

EF