FN Archimer Export Format
PT J
TI Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life
BT 
AF DESTOUMIEUX GARZON, Delphine
   Montagnani, Caroline
   Dantan, Luc
   De San Nicolas, Noémie
   Travers, Agnes
   Duperret, Léo
   Charrière, Guillaume M.
   Toulza, Eve
   Mitta, Guillaume
   Cosseau, Céline
   Escoubas, Jean-Michel
AS 1:1;2:3;3:4;4:5;5:3;6:4;7:5;8:4;9:2;10:4;11:5;
FF 1:;2:PDG-RBE-IHPE;3:;4:;5:PDG-RBE-IHPE;6:;7:;8:;9:PDG-RBE-RMPF;10:;11:;
C1 IHPE, University of Montpellier, CNRS, IFREMER, University of Perpignan Via Domitia,34090 Montpellier, France
   Ifremer, IRD, ILM, Université de Polynésie Française, UMR EIO, Vairao 98179, French Polynesia
   IHPE, University of Montpellier, CNRS, IFREMER, University of Perpignan Via Domitia,34090 Montpellier, France
   IHPE, University of Montpellier, CNRS, IFREMER, University of Perpignan Via Domitia,34090 Montpellier, France
   IHPE, University of Montpellier, CNRS, IFREMER, University of Perpignan Via Domitia,34090 Montpellier, France
C2 CNRS, FRANCE
   IFREMER, FRANCE
   IFREMER, FRANCE
   UNIV PERPIGNAN, FRANCE
   UNIV MONTPELLIER, FRANCE
SI MONTPELLIER
   TAHITI
SE PDG-RBE-IHPE
   PDG-RBE-RMPF
UM IHPE
   EIO
IN WOS Ifremer UMR
   WOS Cotutelle UMR
   copubli-france
   copubli-univ-france
IF 6.3
TC 2
UR https://archimer.ifremer.fr/doc/00883/99477/109536.pdf
LA English
DT Article
DE ;holobiont;microbiome;immunity;homeostasis;immune priming;ontogeny
AB The Pacific oyster Crassostrea gigas lives in microbe-rich marine coastal systems subjected to rapid environmental changes. It harbours a diversified and fluctuating microbiota that cohabits with immune cells expressing a diversified immune gene repertoire. In the early stages of oyster development, just after fertilization, the microbiota plays a key role in educating the immune system. Exposure to a rich microbial environment at the larval stage leads to an increase in immune competence throughout the life of the oyster, conferring a better protection against pathogenic infections at later juvenile/adult stages. This beneficial effect, which is intergenerational, is associated with epigenetic remodelling. At juvenile stages, the educated immune system participates in the control of the homeostasis. In particular, the microbiota is fine-tuned by oyster antimicrobial peptides acting through specific and synergistic effects. However, this balance is fragile, as illustrated by the Pacific Oyster Mortality Syndrome, a disease causing mass mortalities in oysters worldwide. In this disease, the weakening of oyster immune defences by OsHV-1 µVar virus induces a dysbiosis leading to fatal sepsis. This review illustrates the continuous interaction between the highly diversified oyster immune system and its dynamic microbiota throughout its life, and the importance of this cross-talk for oyster health. This article is part of the theme issue ‘Sculpting the microbiome: how host factors determine and respond to microbial colonization’. 
PY 2024
PD MAY
SO Philosophical Transactions Of The Royal Society B-biological Sciences
SN 0962-8436
PU The Royal Society
VL 379
IS 1901
UT 001186396600016
DI 10.1098/rstb.2023.0065
ID 99477
ER

EF