How may fish domestication participate in sustainable development of aquaculture? The development of fish farming currently compensates for the stagnation of fishery catches while the market demand continues to increase. The development of fish farming relies on an active diversification of farmed fish species. A diversification based on the farming of native species could reduce the environmental impact of fish culture and could better fit to needs of local markets. Such development could also favour a more integrated local economy. In this context, the building of a generic approach for multi-species domestication is required to optimise the use of the technical and financial means available for fish culture diversification.