Microwave Sea Surface Salinity (SSS) measurements can be performed by isolating the emissivity response to salinity changes from numerous geophysical effects, including surface temperature and wind waves. At L-band frequencies (1 to 2 GHz), the sensitivity to SSS is sufficient but it falls off quickly as frequency is increased. Nevertheless, methods using higher microwave frequencies with much lower SSS sensitivity than at L band, can already be tested. In particular, combining 6 and 10 GHz data in vertical polarization efficiently minimizes sea surface roughness and thermal impacts. Using AMSR-E data, the retrieved bi-monthly maps of SSS at 0.5 degrees resolution over the region of the Amazon plume show relative accuracy in-line with the future L-band dedicated mission objectives. Citation: Reul, N., S. Saux-Picart, B. Chapron, D. Vandemark, J. Tournadre, and J. Salisbury (2009), Demonstration of ocean surface salinity microwave measurements from space using AMSR-E data over the Amazon plume, Geophys. Res. Lett., 36, L13607, doi:10.1029/2009GL038860.