New short peptaibols from a marine Trichoderma strain

Type Article
Date 2006-03
Language English
Author(s) Mohamed Benkada M1, Montagu M1, Biard J1, Mondeguer FlorenceORCID2, Verite P3, Dalgalarrondo M4, Bissett J5, Pouchus Y1
Affiliation(s) 1 : Univ Nantes, Grp SMAB, EA 2160, Fac Pharm, F-44035 Nantes 1, France.
2 : IFREMER, Ctr Nantes, DEL PN, Nantes 3, France.
3 : UFR Mixte Med Pharm, Lab Chim Analyt, F-76183 Rouen, France.
4 : INRA, LEIMA, F-44316 Nantes 3, France.
5 : Agr & Agri Food Canada, ECORC, Ottawa, ON K1A 0C6, Canada.
Source Rapid communications in mass spectrometry (0951-4198) (John Wiley Interscience), 2006-03 , Vol. 20 , N. 8 , P. 1176-1180
DOI 10.1002/rcm.2430
WOS© Times Cited 43
Keyword(s) Trichoderma longibrachiatum, Marine fungi, Marine products, Electrospray ionisation multiple stage mass spectrometry ion trap (ESI MSn IT), Short peptaibols
Abstract The production of peptaibols by a marine-related Trichoderma longibrachiatum strain was studied using electrospray ionisation multiple-stage ion trap mass spectrometry (ESI-MSn-IT) and gas chromatography/electron impact mass spectrometry (GC/EI-MS). Two major groups of peptaibols were identified, those with long sequences (20 amino acids) and others with short sequences (11 amino acids). This paper describes the methodology used to establish the sequences of short peptaibols in a mixture without previous individual separation. Nine peptaibols were identified. Among them, eight are new, namely as trichobrachin A I-IV (Aib(9)-Pro(10) sequence) and as trichobrachin B I-IV (Val(9)-Pro(10) sequence). Original Pro(6)-Val(7) and Val(9)-Pro(10) sequences have to be noted.
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Mohamed Benkada M, Montagu M, Biard J, Mondeguer Florence, Verite P, Dalgalarrondo M, Bissett J, Pouchus Y (2006). New short peptaibols from a marine Trichoderma strain. Rapid communications in mass spectrometry, 20(8), 1176-1180. Publisher's official version : , Open Access version :