Multixenobiotic resistance protein expression in Mytilus edulis, M-galloprovincialis and Crassostrea gigas from the French coasts

Type Article
Date 2006-09
Language English
Author(s) Minier C1, Moore M2, Galgani FrancoisORCID1, Claisse Didier1
Affiliation(s) 1 : IFREMER, Dept Biogeochim & Ecotoxicol, F-44311 Nantes, France.
2 : Plymouth Marine Lab, Plymouth PL1 3DH, Devon, England.
Source Marine Ecology Progress Series (0171-8630) (Inter-Research), 2006-09 , Vol. 322 , P. 143-154
WOS© Times Cited 10
Keyword(s) Crassostrea gigas, Mytilus galloprovincialis, Mytilus edulis, Biomonitoring, P glycoprotein, MXR
Abstract Multixenobiotic resistance (MXR) is a membrane-transport mechanism that allows organisms to exclude many compounds from their cells and tissues. It is thus a first line of defence against a variety of toxic compounds. Since mussels and oysters possess MXR proteins, an analysis of the expression level of these membrane-transporters has been conducted in relation to their body burden of some major environmental contaminants. Mussels Mytilus edulis and M. galloprovincialis and the oyster Crassostrea gigas were sampled from a total of 43 sites along the French coasts. High expression levels were found in animals from the major French estuaries (Seine, Loire and Gironde), at a few sites in Brittany and in nearly all sites from the Mediterranean mainland coasts. Multivariate analysis of the data for both species of blue mussel did show significant differences between groups of samples. Results indicated that expression of MXR protein was strongly associated with contaminant concentrations in mussels, and that polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) were directly correlated with MXR protein concentration. However, multivariate analysis of oysters, which were collected in less-contaminated sites, at least for organic pollutants, did not show any significant differences between MXR protein expression and contaminants. Although the results do not infer a causal linkage between mussel MXR protein, PAHs and PCBs, since many other chemical contaminants are also present at some sites, they do show clearly that MXR protein expression can be used as an indicator of pollutant exposure in blue mussels. The findings also highlight the need to use alternative analytical methods for the interpretation of complex environmental data, and that non-parametric multivariate statistical methods are appropriate for this task.
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Minier C, Moore M, Galgani Francois, Claisse Didier (2006). Multixenobiotic resistance protein expression in Mytilus edulis, M-galloprovincialis and Crassostrea gigas from the French coasts. Marine Ecology Progress Series, 322, 143-154. Open Access version :