This study was aimed at modeling, as realistically as possible, the dynamics and thermodynamics of the Iroise Sea by using the Model for Applications at Regional Scale (MARS), a regional ocean 3D model. The horizontal resolution of the configuration in use is 2 km with 30 vertical levels. The 3D model of the Iroise Sea is embedded in a larger model providing open boundary conditions. As regards the atmospheric forcing, the originality of this study is to force the regional ocean model with the high-resolution (6 km) regional meteorological model, Weather Research and Forecasting (WRF). In addition, as the air surface temperature is highly sensitive to the sea surface temperature (SST), this regional meteorological model is improved by taking into account a regional climatologic SST to compute meteorological parameters. By allowing a better coherence between the SST and the temperature of the atmospheric boundary layer while giving a more realistic representation of heat fluxes exchanged at the air/sea interface, this forcing constitutes a noticeable improvement of the Iroise Sea modeling. The different sensitivity tests discussed here pinpoint the importance of entering, in WRF, SST data of sufficiently high quality before the computation of meteorological forcing when the aim is a study of dynamics and thermodynamics far away from the coast. On the other hand, when the target is the reproduction of coastal small-scale features in Iroise Sea modeling, the resolution of the meteorological forcing and the quality of SST are both paramount. The simulation of reference was carried out throughout the Summer and Autumn of year 2005 to allow comparisons with a campaign of surface current measurements by high-frequency radars conducted at the same period.