New access to 1,3-diketones from aldehydes

A simple and efficient methodology to introduce an 1,3-diketone motif from various aldehyde precursors in three steps with good overall yields is described using beta-ketosulphone 7 as masked equivalent of acetone.

Keyword(s)

1,3 diketones, Alkylation, Sulfones, Aldehydes

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Fargeas Valérie, Baalouch Myriam, Metay Estelle, Baffreau Jerôme, Menard Delphine, Gosselin Pascal, Berge Jean-Pascal, Barthomeuf Chantal, Lebreton Jacques (2004). New access to 1,3-diketones from aldehydes. Tetrahedron. 60 (45). 10359-10364. https://doi.org/10.1016/j.tet.2004.07.087, https://archimer.ifremer.fr/doc/00000/829/

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