Author(s) Fargeas Valérie , Baalouch Myriam , Metay Estelle , Baffreau Jerôme , Menard Delphine , Gosselin Pascal , Berge Jean-Pascal , Barthomeuf Chantal , Lebreton Jacques Affiliation(s) CNRS, Fac Sci & Tech, UMR 6513, Organ Synth Lab, F-44322 Nantes 3, France. Univ Maine, Fac Sci, CNRS, UMR 6511,Lab Synth Organ, F-72085 Le Mans, France. IFREMER, Dept Valorisat Prod Mer, F-44311 Nantes 3, France. Univ Auvergne, Fac Pharm, Lab Pharmacognosie & Biotechnol, UMR,U 484,INSERM, F-63001 Clermont Ferrand, France.
Source Tetrahedron (0040-4020) (Elsevier), 2004-11, Vol. 60, N. 45, P. 10359-10364
A simple and efficient methodology to introduce an 1,3-diketone motif from various aldehyde precursors in three steps with good overall yields is described using beta-ketosulphone 7 as masked equivalent of acetone.
Keyword(s) 1,3 diketones , Alkylation , Sulfones , Aldehydes