The REPAMO is a French Network for the surveillance of Mollusc diseases that notably meets the obligations of the European Directive 2006/088/EC. It is entirely funded by the French State. The coordination of this network entrusted to the Institut Français de Recherche pour l`Exploitation de la Mer since 1986 aims at monitoring the notifiable endemic diseases, detecting the emergence of exotic or new pathogens and ensuring a minimum level of surveillance of the general health condition of molluscs. Beside IFREMER, different partners are involved in the surveillance of mollusc health at the national level: the Departmental direction for territories and sea who are the local representatives of the competent authority and the producers who have the obligation to notify any suspicion or any abnormal mortality. The network REPAMO thus relies on active and passive strategies. It collects and manages data related to laboratory tests and information concerning sampling that are recorded in a national not open accessible database (also named REPAMO) to respect confidentiality of some data. Results are analysed and edited at least annually under a report format which is sent to all the network partners. The test results allow mapping the geographic distribution of targeted pathogens including notifiable ones and have highlighted certain spatio temporal trends in mortality outbreaks. The network adapts its strategy according to the epidemiological context, the evolution of the production in terms of organisation, quantity and diversity of species, the evolution of the regulation and the knowledge of the diseases it deals with.