Antiviral Activities of Sulfated Polysaccharides Isolated from Sphaerococcus coronopifolius (Rhodophytha, Gigartinales) and Boergeseniella thuyoides (Rhodophyta, Ceramiales)

Type Publication
Date 2011-07
Language English
Copyright 2011 MDPI
Author(s) Bouhlal Rhimou1, 2, Haslin Camille3, Chermann Jean-Claude3, Colliec-Jouault SylviaORCID4, Sinquin CorinneORCID4, Simon Gaelle5, Cerantola Stephane5, Riadi Hassane2, Bourgougnon Nathalie1
Affiliation(s) 1 : Univ Bretagne Sud Vannes, UEB, Ctr Rech Yves Coppens, LBCM, Vannes, France.
2 : Univ Abdelmalek Essaadi, Fac Sci, Lab Diversite & Conservat Syst Biol LDICOSYB, Tetouan 93003, Morocco.
3 : Ctr Vie Agora, URRMA R&D, F-13781 Zi Des Paluds, Aubagne, France.
4 : IFREMER, Lab Biotechnol & Mol Marines, F-44311 Nantes, France.
5 : Univ Bretagne Occidentale, Univ Europeenne Bretagne, Serv Commun Resonance Magnet Nucl, UFR Sci & Tech, F-29238 Brest 3, France.
Source Marine Drugs (1660-3397) (Mdpi Ag), 2011-07 , Vol. 9 , N. 7 , P. 1187-1209
DOI 10.3390/md9071187
WOS© Times Cited 50
Keyword(s) Herpes simplex virus, human immunodeficiency virus, antiviral activity, sulfated polysaccharide, S. coronopifolius, B. thuyoides, chemical composition
Abstract Water-soluble sulfated polysaccharides isolated from two red algae Sphaerococcus coronopifolius (Gigartinales, Sphaerococcaceae) and Boergeseniella thuyoides (Ceramiales, Rhodomelaceae) collected on the coast of Morocco inhibited in vitro replication of the Human Immunodeficiency Virus (HIV) at 12.5 mu g/mL. In addition, polysaccharides were capable of inhibiting the in vitro replication of Herpes simplex virus type 1 (HSV-1) on Vero cells values of EC(50) of 4.1 and 17.2 mu g/mL, respectively. The adsorption step of HSV-1 to the host cell seems to be the specific target for polysaccharide action. While for HIV-1, these results suggest a direct inhibitory effect on HIV-1 replication by controlling the appearance of the new generations of virus and potential virucidal effect. The polysaccharides from S. coronopifolius (PSC) and B. thuyoides (PBT) were composed of galactose, 3,6-anhydrogalactose, uronics acids, sulfate in ratios of 33.1, 11.0, 7.7 and 24.0% (w/w) and 25.4, 16.0, 3.2, 7.6% (w/w), respectively.
Full Text
File Pages Size Access
Publisher's official version 23 353 KB Open access
Top of the page

How to cite 

Bouhlal Rhimou, Haslin Camille, Chermann Jean-Claude, Colliec-Jouault Sylvia, Sinquin Corinne, Simon Gaelle, Cerantola Stephane, Riadi Hassane, Bourgougnon Nathalie (2011). Antiviral Activities of Sulfated Polysaccharides Isolated from Sphaerococcus coronopifolius (Rhodophytha, Gigartinales) and Boergeseniella thuyoides (Rhodophyta, Ceramiales). Marine Drugs, 9(7), 1187-1209. Publisher's official version : https://doi.org/10.3390/md9071187 , Open Access version : https://archimer.ifremer.fr/doc/00060/17120/