Pharmaceuticals are widely released in aquatic environment through treated wastewaters. They reach coastal zone indirectly via streams or directly though marine outfalls however data concerning this contamination in coastal waters are scarce. Environmental Risk Assessment (ERA) of pharmaceuticals have been conducted mostly in surface waters and has not been performed in coastal zone. The first step of ERA is to evaluate the exposure through predictive environmental concentration (PEC) values. The aim of this study was to predict the occurrence of some pharmaceuticals in a coastal aera subjected to treated wastewater (TWW) reject through a marine outfall (Fig 2.). Among pharmaceuticals, Carbamazepine, Oxcarbazepine and their main metabolites (Fig 1.) were chosen. CBZ has been proposed as an indicator of wastewater contamination and has been already detected in Mediterranean (Munaron et al., 2011). Prediction was performed based on local pharmaceuticals consumption recording and a review of pharmacokinetics data. PECs values were estimated in TWW and at the marine outfall and compared with MECs obtained by direct quantification and with POCIS implementation.