Predicted environmental concentrations of carbamazepine, oxcarbazepine and their main metabolites in a coastal system
|Author(s)||Fenet Helene1, Arpin-Pont Lauren1, Vanhoutte Brunier Alice2, Munaron Dominique2, Fiandrino Annie2, Hilaire-Buys Dominique3, Mathieu Olivier3, Budzinski Helene4, Chiron Serge1, Boillot Clotilde1, Gomez Elena1|
|Affiliation(s)||1 : Université Montpellier 1, UMR 5569 Hydrosciences Montpellier, Montpellier, France
2 : IFREMER, Laboratoire Environnement et Ressources du Languedoc-Roussillon (LER-LR), Sète, France
3 : CHU Montpellier, Laboratoire de Pharmacologie Médicale et Toxicologie, Hôpital Lapeyronie, Montpellier, France
4 : Univ Bordeaux, EPOC - UMR 5805 CNRS, Talence, France
|Meeting||6th SETAC World Congress 2012, 20-24 May 2012, Berlin|
|Abstract||Pharmaceuticals are widely released in aquatic environment through treated wastewaters. They reach coastal zone indirectly via streams or directly though marine outfalls however data concerning this contamination in coastal waters are scarce.
Environmental Risk Assessment (ERA) of pharmaceuticals have been conducted mostly in surface waters and has not been performed in coastal zone. The first step of ERA is to evaluate the exposure through predictive environmental concentration (PEC) values.
The aim of this study was to predict the occurrence of some pharmaceuticals in a coastal aera subjected to treated wastewater (TWW) reject through a marine outfall (Fig 2.). Among pharmaceuticals, Carbamazepine, Oxcarbazepine and their main metabolites (Fig 1.) were chosen. CBZ has been proposed as an indicator of wastewater contamination and has been already detected in Mediterranean (Munaron et al., 2011).
Prediction was performed based on local pharmaceuticals consumption recording and a review of pharmacokinetics data. PECs values were estimated in TWW and at the marine outfall and compared with MECs obtained by direct quantification and with POCIS implementation.