Crystal Structure of PAV1-137: A Protein from the Virus PAV1 That Infects Pyrococcus abyssi

Type Article
Date 2013
Language English
Author(s) Leulliot N.1, 2, 3, Quevillon-Cheruel S.1, Graille M.1, 4, Geslin Claire5, Flament DidierORCID6, Le Romancer Marc5, Van Tilbeurgh H.1
Affiliation(s) 1 : Univ Paris 11, CNRS, Inst Biochim & Biophys Mol & Cellulaire, UMR 8619,IFR115, F-91405 Orsay, France.
2 : Univ Paris 05, Fac Sci Pharmaceut & Biol, Lab Cristallog, F-75270 Paris 06, France.
3 : Univ Paris 05, Fac Sci Pharmaceut & Biol, RMN Biol CNRS UMR 8015, F-75270 Paris 06, France.
4 : Ecole Polytech, CNRS, Lab Biochim BIOC, UMR 7654, F-91128 Palaiseau, France.
5 : Univ Brest, CNRS, IFREMER, Lab Microbiol Environm Extremes,UMR 6197,OSU IUEM, F-29280 Plouzane, France.
Source Archaea-an International Microbiological Journal (1472-3646) (Hindawi Publishing Corporation), 2013 , N. ID 568053 , P. 1-5
DOI 10.1155/2013/568053
WOS© Times Cited 2
Abstract Pyrococcus abyssi virus 1 (PAV1) was the first virus particle infecting a hyperthermophilic Euryarchaeota (Pyrococcus abyssi strain GE23) that has been isolated and characterized. It is lemon shaped and is decorated with a short fibered tail. PAV1 morphologically resembles the fusiform members of the family Fuselloviridae or the genus Salterprovirus. The 18 kb dsDNA genome of PAV1 contains 25 predicted genes, most of them of unknown function. To help assigning functions to these proteins, we have initiated structural studies of the PAV1 proteome. We determined the crystal structure of a putative protein of 137 residues (PAV1-137) at a resolution of 2.2 angstrom. The protein forms dimers both in solution and in the crystal. The fold of PAV1-137 is a four-alpha-helical bundle analogous to those found in some eukaryotic adhesion proteins such as focal adhesion kinase, suggesting that PAV1-137 is involved in protein-protein interactions.
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Leulliot N., Quevillon-Cheruel S., Graille M., Geslin Claire, Flament Didier, Le Romancer Marc, Van Tilbeurgh H. (2013). Crystal Structure of PAV1-137: A Protein from the Virus PAV1 That Infects Pyrococcus abyssi. Archaea-an International Microbiological Journal, (ID 568053), 1-5. Publisher's official version : , Open Access version :