A novel "Integrated Biomarker Response" calculation based on reference deviation concept

Type Article
Date 2013-05
Language English
Author(s) Sanchez Wilfried1, Burgeot Thierry2, Porcher Jean-Marc1
Affiliation(s) 1 : Inst Natl Environm Ind & Risques INERIS, Unite Ecotoxicol In Vitro & In Vivo, F-60550 Verneuil En Halatte, France.
2 : Inst Francais Rech Exploitat Mer IFREMER, Unite Ecotoxicol, F-44311 Nantes 3, France.
Source Environmental Science And Pollution Research (0944-1344) (Springer Heidelberg), 2013-05 , Vol. 20 , N. 5 , P. 2721-2725
DOI 10.1007/s11356-012-1359-1
WOS© Times Cited 184
Keyword(s) Biomarkers, Data analysis, Graphic tools, Three-spined stickleback
Abstract Multi-biomarker approaches are used to assess ecosystem health and identify impacts of environmental stress on organisms. However, exploration of large datasets by environmental managers represents a major challenge for regulatory application of this tool. Several integrative tools were developed to summarize biomarker responses. The aim of the present paper is to update calculation of the "Integrated Biological Response" (IBR) described by Beliaeff and Burgeot (Environ Toxicol Chem 21:1316-1322, 2002) to avoid weaknesses of this integrative tool. In the present paper, a novel index named "Integrated Biological Responses version 2" based on the reference deviation concept is presented. It allows a clear discrimination of sampling sites as for the IBR, but several differences are observed for contaminated sites according to up- and downregulation of biomarker responses. This novel tool could be used to integrate multi-biomarker responses not only in large-scale monitoring but also in upstream/downstream investigations.
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