A Dynamic Energy Budget(DEB) model was used to analyse growth and toxin elimination processes in musselsthat had been exposed to Diarrhetic Shellfish Toxins (DST). After DST exposure mussels were placed inan experimentalin-situ setup, expected to have low concentrations of toxic phytoplankton, and DST concentrations in mussel tissueswere regularly monitored along with temperature and seston concentration and composition in the water. A one-compartment model for DST concentrations and elimination rate was integrated with the DEB model, assuming that storage and structural compartments absorb DST. The model was used to simulate growth and toxin elimination rates from mussel tissues. Toxin elimination rate was obtained by a calibration between observed and simulated DST concentrations in mussel tissues over the experimental period. The results demonstratethat tissue concentrations of DST decrease temporally due to the dilution effects from growth, but dilution alone wasnot sufficient to explain the observed elimination rates. Thus there seems to be an active elimination processof toxins in mussels, which in conjunction with dilution through growth contributes to the decreasing DST concentrations in mussels over time.