We present the first large-scale, high-resolution spatial and temporal pattern of disease mortality caused by Ostreid herpesvirus 1 (OsHV-1) that has affected Pacific oyster Crassostrea gigas in France every year since 2008, in relation to local farm use. Mortality was monitored in healthy oyster spat deployed at 106 locations in the Thau Mediterranean lagoon during the epizootic that occurred in spring 2011. We conducted a field survey of farming practices in the areas where the sentinel oysters were placed before the epizootic. We found that the risk of disease mortality in sentinel oysters was higher within the bivalve farming area than outside it, suggesting that the infection pressure is much higher in areas with intensive farming activity. The risk of mortality was higher in farms rearing spat, a developmental stage particularly susceptible to OsHV-1, than in farms rearing adult oysters, which are generally more resistant. Additionally, the mortality risk in farms rearing adult animals was similar to that in empty farms, which suggests that, during the study period, adult oysters did not vector the disease. Interestingly, the mortality risk for sentinel oysters deployed in mussel Mytilus galloprovincialis farms was lower than for those held in oyster farms or empty farms, suggesting that mussels reduced the infection pressure on susceptible oysters.