The English Channel cuttlefish (Sepia officinalis) is the most abundant cephalopod resource in the Northeast Atlantic and one of the three most valuable resources for English Channel fishers. Depletion methods and age-structured models have been used to assess the stock, though they have shown limitations related to the model assumptions and data demand. A two-stage biomass model is, therefore, proposed here using, as input data, four abundance indices derived from survey and commercial trawl data collected by Ifremer and Cefas. The model suggests great interannual variability in abundance during the 17 years of the period considered and a decreasing trend in recent years. Model results suggest that recruitment strength is independent of spawning-stock biomass, but appears to be influenced by environmental conditions such as sea surface temperature at the start of the life cycle. Trends in exploitation rate do not reveal evidence of overexploitation. Reference points are proposed and suggestions for management of the sustainable utilization of cuttlefish in the English Channel are advanced.