Hypoxic episode during the larval period has long-term effects on European sea bass juveniles (Dicentrarchus labrax)

Type Article
Date 2015-02
Language English
Author(s) Vanderplancke Gwenaelle1, Claireaux Guy1, 2, Quazuguel PatrickORCID1, Madec Lauriane1, Ferraresso Serena3, Severe Armelle1, Zambonino-Infante Jose-LuisORCID1, Mazurais DavidORCID1
Affiliation(s) 1 : IFREMER, Ctr Brest, LEMAR UMR CNRS UBO IRD 6539, ZI La Pointe Du Diable,CS 10070, F-29280 Plouzane, France.
2 : IFREMER, UBO, LEMAR UMR CNRS UBO IRD 6539, ZI La Pointe Du Diable, F-29280 Plouzane, France.
3 : Univ Padua, Dept Comparat Biomed & Food Sci, I-35020 Legnaro, Italy.
Source Marine Biology (0025-3162) (Springer Heidelberg), 2015-02 , Vol. 162 , N. 2 , P. 367-376
DOI 10.1007/s00227-014-2601-9
WOS© Times Cited 24
Abstract Hypoxia episodes have been generally studied over the last decade for their lethal consequences in coastal areas, which are nurseries for several fish species. The possible long-lasting effects of non-lethal hypoxia exposures at larval stage are, however, poorly documented. We investigated the long-lasting phenotypic impact of an experimental exposure to moderate hypoxia (40 % air saturation) between 30 and 38 days post-hatching in European sea bass (Dicentrarchus labrax). At the juvenile stage, our data indicate that this early hypoxia exposure impacted on juvenile growth rate but not on hypoxia tolerance. Growth depression was associated with a regulation of metabolism as suggested by a decrease in blood glycaemia, a decreased hepatic expression of the glucose transporter glut2 and of acaca involved in fatty acid synthesis as well as an increased hepatic expression of glycolytic ldh-a, which is a target gene of hypoxia inducible factors (HIFs). Interestingly, while fish were not exposed to hypoxia, the cellular oxygen sensor egln3 gene, which is also a target of HIFs, exhibited higher expression level in the hepatic tissue of juveniles that have experienced hypoxia at larval stage. Even if further studies are needed to evaluate the functional significance of such effects and to decipher the underlying molecular mechanisms, the present data evidence that early life exposure to a hypoxia event has long-lasting impact on sea bass juvenile physiology.
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Vanderplancke Gwenaelle, Claireaux Guy, Quazuguel Patrick, Madec Lauriane, Ferraresso Serena, Severe Armelle, Zambonino-Infante Jose-Luis, Mazurais David (2015). Hypoxic episode during the larval period has long-term effects on European sea bass juveniles (Dicentrarchus labrax). Marine Biology, 162(2), 367-376. Publisher's official version : https://doi.org/10.1007/s00227-014-2601-9 , Open Access version : https://archimer.ifremer.fr/doc/00254/36517/