Autophagy plays an important role in protecting Pacific oysters from OsHV-1 and Vibrio aestuarianus infections

Type Article
Date 2015-03
Language English
Author(s) Moreau Pierrick1, Moreau Kevin2, Segarra Amelie1, Tourbiez Delphine1, Travers Marie-AgnesORCID1, Rubinsztein David C.2, Renault Tristan1
Affiliation(s) 1 : IFREMER, Lab Genet & Pathol Mollusques Marins, Ronce Les Bains, La Tremblade, France.
2 : Cambridge Inst Med Res, Dept Med Genet, Cambridge, England.
Source Autophagy (1554-8627) (Taylor & Francis Inc), 2015-03 , Vol. 11 , N. 3 , P. 516-526
DOI 10.1080/15548627.2015.1017188
WOS© Times Cited 85
Keyword(s) autophagy, Crassostrea gigas, OsHV-1, Pacific oyster, Vibrio aestuarianus, ATG, autophagy-related, Atg8-PE, Atg8-phosphatidylethenolamine, DNA, deoxyribonucleic acid, hpi, hours postinfection, LC3-II, cleaved, lipidated and autophagosome-associated form of LC3, MAP1LC3A, B (LC3A, B), microtubule-associated proteins 1 light chain 3 alpha
Abstract Recent mass mortality outbreaks around the world in Pacific oysters, Crassostrea gigas, have seriously affected the aquaculture economy. Although the causes for these mortality outbreaks appear complex, infectious agents are involved. Two pathogens are associated with mass mortality outbreaks, the virus ostreid herpesvirus 1 (OsHV-1) and the bacterium Vibrio aestuarianus. Here we describe the interactions between these 2 pathogens and autophagy, a conserved intracellular pathway playing a key role in innate immunity. We show for the first time that autophagy pathway is present and functional in Pacific oysters and plays an important role to protect animals from infections. This study contributes to better understand the innate immune system of Pacific oysters.
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