Interaction between toxic dinoflagellate Alexandrium catenella exposure and disease associated with herpesvirus OsHV-1μVar in Pacific oyster spat Crassostrea gigas

Type Article
Date 2015-05
Language English
Author(s) Lassudrie MalwennORCID1, Soudant Philippe1, Nicolas Jean-Louis2, Fabioux Caroline1, Lambert Christophe1, Miner Philippe2, Le Grand Jacqueline3, Petton Bruno3, Hegaret HeleneORCID1
Affiliation(s) 1 : Inst Univ Europeen Mer, UMR CNRS UBO IRD IFREMER 6539, Lab Sci Environm Marin LEMAR, F-29280 Plouzane, France.
2 : IFREMER, Lab Sci Environm Marin LEMAR, IRD,CS 10070, Ctr Bretagne,ZI Pointe du Diable,CNRS,UMR UBO 653, F-29280 Plouzane, France.
3 : IFREMER, Lab Sci Environm Marin LEMAR, IRD, CNRS,UMR UBO 6539, F-29840 Argenton En Landunvez, France.
Source Harmful Algae (1568-9883) (Elsevier Science Bv), 2015-05 , Vol. 45 , P. 53-61
DOI 10.1016/j.hal.2015.04.007
WOS© Times Cited 11
Keyword(s) Crassostrea gigas, OsHV-1 mu Var, Harmful algal blooms, Alexandrium, Host-pathogen interaction, PST accumulation
Abstract Blooms of toxic dinoflagellates can co-occur with mass mortality events associated with herpesvirus OsHV-1 μVar infection that have been decimating Pacific oyster Crassostrea gigas spat and juveniles every summer since 2008 in France. This study investigated the possible effect of a harmful dinoflagellate, Alexandrium catenella, a producer of Paralytic Shellfish Toxins (PSTs), upon the oyster spat–herpesvirus interaction. Oyster spat from a hatchery were challenged by cohabitation with oysters contaminated in the field with OsHV-1 μVar and possibly other pathogens. Simultaneously, the oysters were exposed to cultured A. catenella. Infection with OsHV-1 μVar and PST accumulation were measured after 4 days of experimental exposure.

Exposure to Alexandrium catenella modified the host–pathogen interaction by reducing prevalence of OsHV-1 μVar infection. In addition, oysters challenged with OsHV-1 μVar and possibly other pathogens from the environment accumulated smaller amounts of PSTs than unchallenged oysters. Three possible mechanisms are suggested by these results: (i) possible direct interactions between A. catenella and herpesvirus (or associated pathogens) could reduce viral transmission and algal availability for oyster consumption; (ii) oyster feeding behavior or digestive functions may have been altered, thus decreasing both uptake of viral particles and consumption or digestion of toxic algae and consequent toxin accumulation; (iii) immuno-activation by A. catenella could enhance defense efficiency against OsHV-1 μVar infection. These findings suggest further research on relationships between OsHV-1 μVar and toxic dinoflagellates and their combined effects upon disease transmission and proliferation processes, as well as on oyster physiological and immunological involvement in this complex, tripartite interaction.
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Lassudrie Malwenn, Soudant Philippe, Nicolas Jean-Louis, Fabioux Caroline, Lambert Christophe, Miner Philippe, Le Grand Jacqueline, Petton Bruno, Hegaret Helene (2015). Interaction between toxic dinoflagellate Alexandrium catenella exposure and disease associated with herpesvirus OsHV-1μVar in Pacific oyster spat Crassostrea gigas. Harmful Algae, 45, 53-61. Publisher's official version : https://doi.org/10.1016/j.hal.2015.04.007 , Open Access version : https://archimer.ifremer.fr/doc/00269/38000/