Advances in gastropod immunity from the study of the interaction between the snail Biomphalaria glabrata and its parasites: A review of research progress over the last decade

Type Article
Date 2015-09
Language English
Author(s) Coustau C.1, Gourbal B.5, Duval D.5, Yoshino T. P.3, Adema C. M.4, Mitta GuillaumeORCID2
Affiliation(s) 1 : INRA CNRS UNS, Sophia Agrobiotech Inst, Sophia Antipolis, France.
2 : Univ Montpellier, IFREMER, CNRS, IHPE UMR 5244,Univ Perpignan Via Domitia, F-66860 Perpignan, France.
3 : Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA.
4 : Univ New Mexico, Dept Biol, Ctr Evolutionary & Theoret Immunol, Albuquerque, NM 87131 USA.
5 : Univ Montpellier, IFREMER, CNRS, IHPE UMR 5244,Univ Perpignan Via Domitia, F-66860 Perpignan, France.
Source Fish & Shellfish Immunology (1050-4648) (Academic Press Ltd- Elsevier Science Ltd), 2015-09 , Vol. 46 , N. 1 , P. 5-16
DOI 10.1016/j.fsi.2015.01.036
WOS© Times Cited 77
Note SI: Molluscan Immunity
Keyword(s) Biomphalaria glabrata, Schistosoma mansoni, Echinostoma caproni, Immunity, Compatibility
Abstract This review summarizes the research progress made over the past decade in the field of gastropod immunity resulting from investigations of the interaction between the snail Biomphalaria glabrata and its trematode parasites. A combination of integrated approaches, including cellular, genetic and comparative molecular and proteomic approaches have revealed novel molecular components involved in mediating Biomphalaria immune responses that provide insights into the nature of host-parasite compatibility and the mechanisms involved in parasite recognition and killing. The current overview emphasizes that the interaction between B. glabrata and its trematode parasites involves a complex molecular crosstalk between numerous antigens, immune receptors, effectors and anti-effector systems that are highly diverse structurally and extremely variable in expression between and within host and parasite populations. Ultimately, integration of these molecular signals will determine the outcome of a specific interaction between a B. glabrata individual and its interacting trematodes. Understanding these complex molecular interactions and identifying key factors that may be targeted to impairment of schistosome development in the snail host is crucial to generating new alternative schistosomiasis control strategies.
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Coustau C., Gourbal B., Duval D., Yoshino T. P., Adema C. M., Mitta Guillaume (2015). Advances in gastropod immunity from the study of the interaction between the snail Biomphalaria glabrata and its parasites: A review of research progress over the last decade. Fish & Shellfish Immunology, 46(1), 5-16. Publisher's official version : https://doi.org/10.1016/j.fsi.2015.01.036 , Open Access version : https://archimer.ifremer.fr/doc/00276/38718/