Modelization of coordinated changes of adenylate energy charge and ATP/ADP ratio: Application to energy metabolism in invertebrate and vertebrate skeletal muscle

Le régulation des variations coordonnées de la charge énergétique adénylique et du rapport ATP/ADP a été étudiée à l'aide d'une simulation par ordinateur. Si on considère que la réaction de l'adénylate kinase fonctionne à l'équilibre, il est possible de dériver une équation simple reliant ces 2 paramètres. La modélisation obtenue a permis l'analyse de l'incidence de la désamination de l’AMP sur la régulation du métabolisme énergétique cellulaire.

Mot-clé(s)

charge énergétique adénylique, ATP/ADP, AMP désaminase, adénylate kinose

Regulation of the coordinated adenylate energy charge (AEC) and ATP/ADP ratio variations was studied with the did of computer-made simulations. When the equilibrium state for the adenylate kinase-catalyzed reaction has been assumed the function describing the coordinated REC and ATP/ADP ratio variations can be simply derived from the formulas describing these 2 parameters. The model was used to analyze incidence of AMP deamination in the coordinated regulation of cellular energy metabolism.

Keyword(s)

adenylate energy charge, ATP/ADP, AMP deaminase, adenylate kinase

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Raffin Jean-Paul, Thebault Marie-Thérèse (1996). Modelization of coordinated changes of adenylate energy charge and ATP/ADP ratio: Application to energy metabolism in invertebrate and vertebrate skeletal muscle. Comptes Rendus de l'Academie des Sciences Serie III-Sciences de la Vie-Life Sciences. 319 (1). 9-15. https://archimer.ifremer.fr/doc/00283/39378/

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