The Kinome of Pacific Oyster Crassostrea gigas, Its Expression during Development and in Response to Environmental Factors
|Author(s)||Epelboin Yanouk1, Quintric Laure2, Guevelou Eric1, 4, Boudry Pierre1, Pichereau Vianney3, Corporeau Charlotte1|
|Affiliation(s)||1 : IFREMER, UMR CNRS UBO IRD Ifremer 6539, Lab Sci Environm Marin, Plouzane, France.
2 : IFREMER, Serv Ressources Informat & Commun, Plouzane, France.
3 : UBO, UMR CNRS UBO IRD Ifremer 6539, Lab Sci Environm Marin, Plouzane, France.
4 : Virginia Inst Marine Sci, Coll William & Mary, Aquaculture Genet & Breeding Technol Ctr, Gloucester Point, VA 23062 USA.
|Source||Plos One (1932-6203) (Public Library Science), 2016-05 , Vol. 11 , N. 5 , P. -|
|WOS© Times Cited||13|
|Abstract||Oysters play an important role in estuarine and coastal marine habitats, where the majority of humans live. In these ecosystems, environmental degradation is substantial, and oysters must cope with highly dynamic and stressful environmental constraints during their lives in the intertidal zone. The availability of the genome sequence of the Pacific oyster Crassostrea gigas represents a unique opportunity for a comprehensive assessment of the signal transduction pathways that the species has developed to deal with this unique habitat. We performed an in silico analysis to identify, annotate and classify protein kinases in C. gigas, according to their kinase domain taxonomy classification, and compared with kinome already described in other animal species. The C. gigas kinome consists of 371 protein kinases, making it closely related to the sea urchin kinome, which has 353 protein kinases. The absence of gene redundancy in some groups of the C. gigas kinome may simplify functional studies of protein kinases. Through data mining of transcriptomes in C. gigas, we identified part of the kinome which may be central during development and may play a role in response to various environmental factors. Overall, this work contributes to a better understanding of key sensing pathways that may be central for adaptation to a highly dynamic marine environment.|