The Kinome of Pacific Oyster Crassostrea gigas, Its Expression during Development and in Response to Environmental Factors

Type Article
Date 2016-05
Language English
Author(s) Epelboin Yanouk1, Quintric Laure2, Guevelou Eric1, 4, Boudry PierreORCID1, Pichereau Vianney3, Corporeau CharlotteORCID1
Affiliation(s) 1 : IFREMER, UMR CNRS UBO IRD Ifremer 6539, Lab Sci Environm Marin, Plouzane, France.
2 : IFREMER, Serv Ressources Informat & Commun, Plouzane, France.
3 : UBO, UMR CNRS UBO IRD Ifremer 6539, Lab Sci Environm Marin, Plouzane, France.
4 : Virginia Inst Marine Sci, Coll William & Mary, Aquaculture Genet & Breeding Technol Ctr, Gloucester Point, VA 23062 USA.
Source Plos One (1932-6203) (Public Library Science), 2016-05 , Vol. 11 , N. 5 , P. -
DOI 10.1371/journal.pone.0155435
WOS© Times Cited 13
Abstract Oysters play an important role in estuarine and coastal marine habitats, where the majority of humans live. In these ecosystems, environmental degradation is substantial, and oysters must cope with highly dynamic and stressful environmental constraints during their lives in the intertidal zone. The availability of the genome sequence of the Pacific oyster Crassostrea gigas represents a unique opportunity for a comprehensive assessment of the signal transduction pathways that the species has developed to deal with this unique habitat. We performed an in silico analysis to identify, annotate and classify protein kinases in C. gigas, according to their kinase domain taxonomy classification, and compared with kinome already described in other animal species. The C. gigas kinome consists of 371 protein kinases, making it closely related to the sea urchin kinome, which has 353 protein kinases. The absence of gene redundancy in some groups of the C. gigas kinome may simplify functional studies of protein kinases. Through data mining of transcriptomes in C. gigas, we identified part of the kinome which may be central during development and may play a role in response to various environmental factors. Overall, this work contributes to a better understanding of key sensing pathways that may be central for adaptation to a highly dynamic marine environment.
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Publisher's official version 24 955 KB Open access
S1 Table. Identified Crassostrea gigas protein kinases. 51 KB Open access
S1 Text. Zhang et al. (2012). 6 711 KB Open access
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