We present a revised tectonostratigraphy of the Jan Mayen microcontinent (JMMC) and its southern extent, with the focus on its relationship to the Greenland–Iceland–Faroe Ridge area and the Faroe–Iceland Fracture Zone. The microcontinent's Cenozoic evolution consists of six main phases corresponding to regional stratigraphic unconformities. Emplacement of Early Eocene plateau basalts at pre-break-up time (56–55 Ma), preceded the continental break-up (55 Ma) and the formation of seawards-dipping reflectors (SDRs) along the eastern and SE flanks of the JMMC. Simultaneously with SDR formation, orthogonal seafloor spreading initiated along the Ægir Ridge (Norway Basin) during the Early Eocene (C24n2r, 53.36 Ma to C22n, 49.3 Ma). Changes in plate motions at C21n (47.33 Ma) led to oblique seafloor spreading offset by transform faults and uplift along the microcontinent's southern flank. At C13n (33.2 Ma), spreading rates along the Ægir Ridge started to decrease, first south and then in the north. This was probably complemented by intra-continental extension within the JMMC, as indicated by the opening of the Jan Mayen Basin – a series of small pull-apart basins along the microcontinent's NW flank. JMMC was completely isolated when the mid-oceanic Kolbeinsey Ridge became fully established and the Ægir Ridge was abandoned between C7 and C6b (24–21.56 Ma).