Changes in Brain Monoamines Underlie Behavioural Disruptions after Zebrafish Diet Exposure to Polycyclic Aromatic Hydrocarbons Environmental Mixtures

Type Article
Date 2017-03
Language English
Author(s) Vignet Caroline1, Trenkel VerenaORCID2, Vouillarmet Annick3, Bricca Giampiero3, Begout Marie-LaureORCID1, Cousin XavierORCID1, 4, 5
Affiliation(s) 1 : IFREMER, Lab Ressources Halieut, Pl Gaby Coll, F-17137 Lhoumeau, France.
2 : IFREMER, Unite Ecol & Modeles Halieut, BP 21105, F-44311 Nantes 03, France.
3 : Univ Lyon 1, Genom Fonct Hypertens Arterielle, EA 4173, 8 Ave Rockefeller, F-69373 Lyon 08, France.
4 : IFREMER, UMR MARBEC, Lab Adaptat & Adaptabilites Anim & Syst, Route Maguelone, F-34250 Palavas Les Flots, France.
5 : Univ Paris Saclay, INRA, GABI, AgroParisTech, F-78350 Jouy En Josas, France.
Source International Journal Of Molecular Sciences (1422-0067) (Mdpi Ag), 2017-03 , Vol. 18 , N. 3 , P. 560 (1-11)
DOI 10.3390/ijms18030560
WOS© Times Cited 4
Note This article belongs to the Special Issue Zebrafish: A Model for Toxicological Research
Keyword(s) monoamine, polycyclic aromatic hydrocarbons, behaviour, anxiety, swimming activity, zebrafish
Abstract Zebrafish were exposed through diet to two environmentally relevant polycyclic aromatic hydrocarbons (PAHs) mixtures of contrasted compositions, one of pyrolytic (PY) origin and one from light crude oil (LO). Monoamine concentrations were quantified in the brains of the fish after six month of exposure. A significant decrease in noradrenaline (NA) was observed in fish exposed to both mixtures, while a decrease in serotonin (5HT) and dopamine (DA) was observed only in LO-exposed fish. A decrease in metabolites of 5HT and DA was observed in fish exposed to both mixtures. Several behavioural disruptions were observed that depended on mixtures, and parallels were made with changes in monoamine concentrations. Indeed, we observed an increase in anxiety in fish exposed to both mixtures, which could be related to the decrease in 5HT and/or NA, while disruptions of daily activity rhythms were observed in LO fish, which could be related to the decrease in DA. Taken together, these results showed that (i) chronic exposures to PAHs mixtures disrupted brain monoamine contents, which could underlie behavioural disruptions, and that (ii) the biological responses depended on mixture compositions
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Vignet Caroline, Trenkel Verena, Vouillarmet Annick, Bricca Giampiero, Begout Marie-Laure, Cousin Xavier (2017). Changes in Brain Monoamines Underlie Behavioural Disruptions after Zebrafish Diet Exposure to Polycyclic Aromatic Hydrocarbons Environmental Mixtures. International Journal Of Molecular Sciences, 18(3), 560 (1-11). Publisher's official version : https://doi.org/10.3390/ijms18030560 , Open Access version : https://archimer.ifremer.fr/doc/00375/48578/