Ocean warming combined with lower omega-3 nutritional availability impairs the cardio-respiratory function of a marine fish

Type Article
Date 2019-04
Language English
Author(s) Vagner Marie1, Pante Eric1, Viricel Amelia1, Lacoue-Labarthe Thomas1, Zambonino-Infante Jose-LuisORCID2, Quazuguel PatrickORCID2, Dubillot Emmanuel1, Huet Valerie1, Le Delliou Herve2, Lefrançois Christel1, Imbert-Auvray Nathalie1
Affiliation(s) 1 : UMR 7266 LIENSs (University of La Rochelle – CNRS), 2 rue Olympe de Gouges 17000 La Rochelle, France
2 : Ifremer, UMR 6539 LEMAR, Center Ifremer ZI Pointe du diable 29280 Plouzané, France
Source Journal Of Experimental Biology (0022-0949) (The Company of Biologists), 2019-04 , Vol. 222 , N. 8 , P. jeb187179 (17p.)
DOI 10.1242/jeb.187179
WOS© Times Cited 8
Keyword(s) Omega-3 highly unsaturated fatty acids, Temperature, Cardiac performance, Swimming performance, Chelon auratus, RNAseq

Highly unsaturated fatty acids of the omega-3 series (HUFA) are major constituents of cell membranes, yet poorly synthesised de novo by consumers. Their production, mainly supported by aquatic microalgae, has been decreasing with global change. Understanding the consequences of such reductions is essential for ectotherm consumers, since temperature tightly regulates the HUFA content in cell membranes, maintaining their functionality. Integrating individual, tissue and molecular approaches, we examined the consequences of the combined effects of temperature and HUFA depletion on the key cardio-respiratory functions of the golden grey mullet, an ectotherm grazer of high ecological importance. For four months, fish were exposed to two contrasting HUFA diets (4.8% ecosapentaenoic acid (EPA)+docosahexaenoic acid (DHA) on dry matter (DM) vs. 0.2% EPA+DHA on DM) at 12°C and 20°C. Ventricular force development coupled with gene expression profiles measured on cardiac muscle suggest that combining HUFA depletion with warmer temperatures leads to (1) a proliferation of sarcolemmal and SR Ca2+ channels and (2) a higher force-generating ability by increasing extracellular Ca2+ influx via sarcolemmal channels when the heart has to sustain excessive effort due to stress and/or exercise. At the individual scale, these responses were associated with a relatively greater aerobic scope, maximum metabolic rate and net cost of locomotion, suggesting the higher energy cost of this strategy. These impaired cardiac performances could have wider consequences on other physiological performances such as growth, reproduction or migration, all greatly depending on heart function.

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Vagner Marie, Pante Eric, Viricel Amelia, Lacoue-Labarthe Thomas, Zambonino-Infante Jose-Luis, Quazuguel Patrick, Dubillot Emmanuel, Huet Valerie, Le Delliou Herve, Lefrançois Christel, Imbert-Auvray Nathalie (2019). Ocean warming combined with lower omega-3 nutritional availability impairs the cardio-respiratory function of a marine fish. Journal Of Experimental Biology, 222(8), jeb187179 (17p.). Publisher's official version : https://doi.org/10.1242/jeb.187179 , Open Access version : https://archimer.ifremer.fr/doc/00476/58744/