In this paper, the mineralogy, fluid inclusions and stable isotopes of hydrothermal veins from the SE part of the Afar Rift (Djibouti) were studied. Mineralization occurs as gold-silver in quartz/carbonate veins and is mainly associated with felsic volcanism. The morphologies and textures of quartz show crustiform colloform banding, massive and breccias. Microthermometric measurements were made on quartz-hosted two phases (liquid + vapor) inclusions. Mean homogenization temperature ranges from 150°C to 340°C and ice-melting temperatures range from -0.2°C to - 1.6°C indicating that inclusion solutions contain 0.35 to 2.7 eq. wt. % NaCl. Furthermore, δ18O and δ13C values from calcite range from 3.7 to 26.6 ‰ and -7.5 to 0.3 ‰, respectively. The presence of platy calcite and adularia are consistent with boiling conditions. Our study shows that the deposit of precious-metal deposition occurred at around 250°C and is linked to a fluid generated by the mixture of magmatic fluid, hydrothermal fluid and seawater.