Paleorecords and modeling studies suggest that instabilities in the Atlantic Meridional Overturning Circulation (AMOC) strongly affect the low-latitude climate, namely via feedbacks on the Atlantic Intertropical Convergence Zone (ITCZ). Despite the pronounced millennial-scale overturning and climatic variability documented in the subpolar North Atlantic during the last interglacial period (MIS 5e), studies on cross-latitudinal teleconnections remain very limited. This precludes a full understanding of the mechanisms controlling subtropical climate evolution across the last warm cycle. Here, we present new planktic foraminiferal assemblage data combined with delta O-18 values in surface and thermocline-dwelling foraminifera from the Bahamas, a region ideally suited to studying past changes in the subtropical ocean and atmosphere. Our data reveal that the peak sea surface warmth during early MIS 5e was intersected by an abrupt millennial-scale cooling/salinification event, which was possibly associated with a sudden southward displacement of the mean annual ITCZ position. This atmospheric shift is, in turn, ascribed to the transitional climatic regime of early MIS 5e, which was characterized by persistent ocean freshening in the high latitudes and an unstable AMOC mode.