Climatic forcing of fluvial systems has been a pre-occupation of geomorphological studies in Australia since the 1940s. In the Riverine Plain, southeastern Australia, the stable tectonic setting and absence of glaciation have combined to produce sediment loads that are amongst the lowest in the world. Surficial sediments and landforms exceed 140,000 yr in age, and geomorphological change recorded in the fluvial, fluvio-lacustrine and aeolian features have provided a well-studied record of Quaternary environmental change over the last glacial cycle. The region includes the Willandra Lakes, whose distinctive lunette lakes preserve a history of water-level variations and ecological change that is the cornerstone of Australian Quaternary chronostratigraphy. The lunette sediments also contain an ancient record of human occupation that includes the earliest human fossils yet found on the Australian continent. To date, the lake-level and palaeochannel records in the Lachlan-Willandra system have not been fully integrated, making it difficult to establish the regional significance of hydrological change. Here, we compare the Willandra Lakes environmental record with the morphology and location of fluvial systems in the lower Lachlan. An ancient channel belt of the Lachlan, Willandra Creek, acted as the main feeder channel to Willandra Lakes before channel avulsion caused the lakes to dry out in the late Pleistocene. Electromagnetic surveys, geomorphological and sedimentary evidence are used to reconstruct the evolution of the first new channel belt following the avulsion. Single grain optical dating of floodplain sediments indicates that sedimentation in the new Middle Billabong Palaeochannel had commenced before 18.4 +/- 1.1 ka. A second avulsion shifted its upper reaches to the location of the present Lachlan River by 16.2 +/- 0.9 ka. The timing of these events is consistent with palaeohydrological records reconstructed from Willandra Lakes and with the record of palaeochannels on the Lachlan River upstream. Willandra Lakes shows high inflows during the Last Glacial Maximum (similar to 22 ka), but their subsequent drying between 20.5 ka and 19 ka was caused by river avulsion rather than regional aridity. This case study highlights the benefits of combining fluvial with lacustrine archives to build complementary records of hydrological change in lowland riverine plains.