Water-soluble poly(3-hydroxyalkanoate) sulfonate: versatile biomaterials used as coatings for highly porous nano-MOF
| Type | Article | ||||||||||||
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| Date | 2019-09 | ||||||||||||
| Language | English | ||||||||||||
| Author(s) | Jain Caroline1, 2, Li Xue3, Houel Renault Ludivine4, Modjinou Tina1, Simon Colin Christelle2, Gref Ruxandra3, Renard Estelle1, Langlois Valérie1 | ||||||||||||
| Affiliation(s) | 1 : Institut de Chimie et des Matériaux Paris-Est, UPEC-CNRS, 2 rue Henry Dunant, 94320 Thiais, France 2 : Ifremer, UMR 6197, Laboratoire de Microbiologie des Environnements Extrêmes (LM2E), Technopôle Pointe du Diable, 29280 Plouzané, France 3 : Institut des Sciences Moléculaires d’Orsay, UMR 8214, CNRS-UPS, Rue André Rivière, 91405 Orsay, France 4 : Centre Laser de l’Université Paris-Sud (CLUPS/LUMAT), CNRS-UPS-IOGS, Université Paris-Saclay, 91405 Orsay, France |
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| Meeting | ISBP2018 - 16th International Symposium on Biopolymers "Biopolymers for a better world". October 21st-24th, 2018, China | ||||||||||||
| Source | Biomacromolecules (1525-7797) (American Chemical Society (ACS)), 2019-09 , Vol. 20 , N. 9 , P. 3324-3332 | ||||||||||||
| DOI | 10.1021/acs.biomac.9b00870 | ||||||||||||
| WOS© Times Cited | 17 | ||||||||||||
| Abstract | Water soluble poly(3-hydroxyalkanoate) containing ionic groups was designed by two successive photo-activated thiol-ene reactions. Sodium-3-mercapto-1-ethanesulfonate (SO3-) and poly(ethylene glycol) methyl ether thiol (PEG) were grafted onto poly(3-hydroxyoctanoate-co-3-hydroxyundecenoate) PHO(67)U(33) to both introduce ionic groups and hydrophilic moieties. The grafted copolymers PHO(67)SO3-(20)PEG(13) were then used as biocompatible coatings of nano-Metal Organic Frameworks surface. Scanning Electron Microscopy and Scanning Transmission Electron Microscopy coupled with Energy Dispersive X-ray characterizations have clearly demonstrated the presence of the copolymer on the MOF surface. These coated nano-MOF are stable in aqueous and physiological fluids. Cell proliferation and cytotoxicity tests performed on murine macrophages J774.A1 revealed no cytotoxic side effect. Thus, biocompatibility and stability of these novel hybrid porous MOF structures encourage their use in the development of effective therapeutic nanoparticles. |
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