One specimen of Ptychoglossus brevifrontalis Boulenger, 1912 was found during a field survey in the core area of the Amazonian National Park of French Guiana in the southern part of the country. Despite intensive herpetological surveys in French Guiana during the last three decades, this is the first record of the species for this country. This new locality extends the distribution of the species and draws attention to the need for more study of litter-dwelling lizards in French Guiana.