Anti-Biofilm Effect of Biodegradable Coatings Based on Hemibastadin Derivative in Marine Environment

Type Article
Date 2017-07
Language English
Author(s) Le Norcy Tiffany1, Niemann Hendrik2, Proksch Peter2, Linossier Isabelle1, Vallee-Rehel Karine1, Hellio Claire3, Fay Fabienne1
Affiliation(s) 1 : Univ Bretagne Sud, Inst Univ Europeen Mer, Lab Biotechnol & Chim Marines, F-56100 Lorient, France.
2 : Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany.
3 : Univ Bretagne Occidentale, Inst Europeen Mer, LEMAR UMR 6539, Biodimar, F-29200 Brest, France.
Source International Journal Of Molecular Sciences (1422-0067) (Mdpi Ag), 2017-07 , Vol. 18 , N. 7 , P. 1520 (19p.)
DOI 10.3390/ijms18071520
WOS© Times Cited 8
Note This article belongs to the Special Issue Biodegradable Materials 2017
Keyword(s) antifouling, biodegradable coating, hemibastadin, sponges, marine bacteria, microalgae
Abstract

Dibromohemibastadin-1 (DBHB) is an already known potent inhibitor of blue mussel phenoloxidase (which is a key enzyme involved in bioadhesion). Within this study, the potentiality of DBHB against microfouling has been investigated. The activity of DBHB was evaluated on key strains of bacteria and microalgae involved in marine biofilm formation and bioassays assessing impact on growth, adhesion and biofilm formation were used. To assess the efficiency of DBHB when included in a matrix, DBHB varnish was prepared and the anti-microfouling activity of coatings was assessed. Both in vitro and in situ immersions were carried out. Confocal Laser Scanning Microscopy (CLSM) was principally used to determine the biovolume and average thickness of biofilms developed on the coatings. Results showed an evident efficiency of DBHB as compound and varnish to reduce the biofilm development. The mode of action seems to be based principally on a perturbation of biofilm formation rather than on a biocidal activity in the tested conditions.

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Le Norcy Tiffany, Niemann Hendrik, Proksch Peter, Linossier Isabelle, Vallee-Rehel Karine, Hellio Claire, Fay Fabienne (2017). Anti-Biofilm Effect of Biodegradable Coatings Based on Hemibastadin Derivative in Marine Environment. International Journal Of Molecular Sciences, 18(7), 1520 (19p.). Publisher's official version : https://doi.org/10.3390/ijms18071520 , Open Access version : https://archimer.ifremer.fr/doc/00616/72812/