|Author(s)||Le Norcy Tiffany1, Niemann Hendrik2, Proksch Peter2, Tait Karen3, Linossier Isabelle1, Rehel Karine1, Hellio Claire4, Fay Fabienne1|
|Affiliation(s)||1 : Univ Bretagne Sud, Inst Univ Europeen Mer, Lab Biotechnol & Chim Marines, F-56100 Lorient, France.
2 : Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany.
3 : Plymouth Marine Lab, Plymouth PL1 3DH, Devon, England.
4 : Univ Bretagne Occidentale, Inst Europeen Mer, LEMAR UMR 6539, Biodimar, F-29200 Brest, France.
|Source||Marine Drugs (1660-3397) (Mdpi Ag), 2017-07 , Vol. 15 , N. 7 , P. 222 (18p.)|
|WOS© Times Cited||6|
|Keyword(s)||biofouling, biofilm, bastadin derivative, microfouling, quorum sensing, sponge|
|Abstract||Since the banning of several families of compounds in antifouling (AF) coatings, the search for environmentally friendly AF compounds has intensified. Natural sources of AF compounds have been identified in marine organisms and can be used to create analogues in laboratory. In a previous study, we identified that dibromohemibastadin-1 (DBHB) is a promising AF molecule, leading to the inhibition of the activity of phenoloxidase, an enzyme involved in the attachment of mussels to surfaces. This paper describes the activity of the DBHB on biofilm formation and its detachment and on bacterial adhesion and communication: quorum sensing. DBHB has an anti-biofilm activity without affecting adhesion of marine and terrestrial bacteria at a dose of 10 mu M. Moreover, DBHB activity on quorum sensing (QS) is demonstrated at doses of 8 and 16 mu M. The activity of DBHB on QS is compared to kojic acid, a quorum sensing inhibitor already described. This compound is a promising environmentally friendly molecule potentially useful for the inhibition of microfouling.|
Le Norcy Tiffany, Niemann Hendrik, Proksch Peter, Tait Karen, Linossier Isabelle, Rehel Karine, Hellio Claire, Fay Fabienne (2017). Sponge-Inspired Dibromohemibastadin Prevents and Disrupts Bacterial Biofilms without Toxicity. Marine Drugs, 15(7), 222 (18p.). Publisher's official version : https://doi.org/10.3390/md15070222 , Open Access version : https://archimer.ifremer.fr/doc/00616/72813/