Sensing Polymer/Paracetamol Interaction with an Independent Component Analysis-Based SERS-MIP Nanosensor

Type Article
Date 2020-10
Language English
Author(s) Decorbie N.1, Tijunelyte I.1, Gam-Derouich S.2, Solard J.3, Lamouri A.2, Decorse P.2, Felidj N.2, Gauchotte-Lindsay C.4, Rinnert EmmanuelORCID5, Mangeney C.2, 6, Lidgi-Guigui N.1
Affiliation(s) 1 : CSPBAT, (now LSPM), Sorbonne Paris Nord, 99 Av. JB Clément, 93430, Villetaneuse, France
2 : Univ Paris Diderot, Sorbonne Paris Cité, ITODYS, UMR CNRS 71086, 75013, Paris, France
3 : Centrale de Proximité en Nanotechnologies de Paris Nord, Sorbonne Paris Nord, 99, Av. JB Clément, 93430, Villetaneuse, France
4 : James Watt School of Engineering, University of Glasgow, Rankine Building, Oakfield Avenue, G12 8LT, Glasgow, UK
5 : IFREMER, RDT-LDCM, Technopole Brest-Iroise, 29280, Plouzané, France
6 : University of Paris, Lab Chim & Biochim Pharmacolog & Toxicol, UMR 8601, 75006, Paris, France
Source Plasmonics (1557-1955) (Springer Science and Business Media LLC), 2020-10 , Vol. 15 , N. 5 , P. 1533-1539
DOI 10.1007/s11468-020-01177-9
WOS© Times Cited 3
Keyword(s) Sensor, SERS, Molecularly imprinted polymers, Emerging pollutant, Paracetamol, Independent component analysis
Abstract

In this article, we propose a new strategy to build a sensor for easy handling and rapid analysis on-site. Our sensor is based on the combination of surface-enhanced Raman spectroscopy (SERS) and molecularly imprinted polymers (MIPs). SERS provides a strong sensitivity for the detection of trace molecules while MIPs offer a highly selective and specific recognition platform. The research presented here focuses on the detection of the interaction between a robust ultra-thin layer of MIPs and of paracetamol, the targeted molecule. This drug is an environmental emerging pollutant, i.e., a molecule whose presence and significance have not yet been elucidated, which gives rise to health and environmental concerns. The results are a combined analysis of the SERS spectra and a multivariate analysis. The former provides a clear demonstration of the evolution of the MIP-nanostructure interaction when the concentration of paracetamol increases. The statistical analysis produces the proof of the selectivity of the sensor

Full Text
File Pages Size Access
Author's final draft 12 780 KB Open access
7 401 KB Access on demand
Top of the page

How to cite 

Decorbie N., Tijunelyte I., Gam-Derouich S., Solard J., Lamouri A., Decorse P., Felidj N., Gauchotte-Lindsay C., Rinnert Emmanuel, Mangeney C., Lidgi-Guigui N. (2020). Sensing Polymer/Paracetamol Interaction with an Independent Component Analysis-Based SERS-MIP Nanosensor. Plasmonics, 15(5), 1533-1539. Publisher's official version : https://doi.org/10.1007/s11468-020-01177-9 , Open Access version : https://archimer.ifremer.fr/doc/00628/73962/