Sensing Polymer/Paracetamol Interaction with an Independent Component Analysis-Based SERS-MIP Nanosensor

Type Article
Date 2020-10
Language English
Author(s) Decorbie N.1, Tijunelyte I.1, Gam-Derouich S.2, Solard J.3, Lamouri A.2, Decorse P.2, Felidj N.2, Gauchotte-Lindsay C.4, Rinnert EmmanuelORCID5, Mangeney C.2, 6, Lidgi-Guigui N.1
Affiliation(s) 1 : CSPBAT, (now LSPM), Sorbonne Paris Nord, 99 Av. JB Clément, 93430, Villetaneuse, France
2 : Univ Paris Diderot, Sorbonne Paris Cité, ITODYS, UMR CNRS 71086, 75013, Paris, France
3 : Centrale de Proximité en Nanotechnologies de Paris Nord, Sorbonne Paris Nord, 99, Av. JB Clément, 93430, Villetaneuse, France
4 : James Watt School of Engineering, University of Glasgow, Rankine Building, Oakfield Avenue, G12 8LT, Glasgow, UK
5 : IFREMER, RDT-LDCM, Technopole Brest-Iroise, 29280, Plouzané, France
6 : University of Paris, Lab Chim & Biochim Pharmacolog & Toxicol, UMR 8601, 75006, Paris, France
Source Plasmonics (1557-1955) (Springer Science and Business Media LLC), 2020-10 , Vol. 15 , N. 5 , P. 1533-1539
DOI 10.1007/s11468-020-01177-9
WOS© Times Cited 11
Keyword(s) Sensor, SERS, Molecularly imprinted polymers, Emerging pollutant, Paracetamol, Independent component analysis

In this article, we propose a new strategy to build a sensor for easy handling and rapid analysis on-site. Our sensor is based on the combination of surface-enhanced Raman spectroscopy (SERS) and molecularly imprinted polymers (MIPs). SERS provides a strong sensitivity for the detection of trace molecules while MIPs offer a highly selective and specific recognition platform. The research presented here focuses on the detection of the interaction between a robust ultra-thin layer of MIPs and of paracetamol, the targeted molecule. This drug is an environmental emerging pollutant, i.e., a molecule whose presence and significance have not yet been elucidated, which gives rise to health and environmental concerns. The results are a combined analysis of the SERS spectra and a multivariate analysis. The former provides a clear demonstration of the evolution of the MIP-nanostructure interaction when the concentration of paracetamol increases. The statistical analysis produces the proof of the selectivity of the sensor

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Decorbie N., Tijunelyte I., Gam-Derouich S., Solard J., Lamouri A., Decorse P., Felidj N., Gauchotte-Lindsay C., Rinnert Emmanuel, Mangeney C., Lidgi-Guigui N. (2020). Sensing Polymer/Paracetamol Interaction with an Independent Component Analysis-Based SERS-MIP Nanosensor. Plasmonics, 15(5), 1533-1539. Publisher's official version : , Open Access version :