Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge Pseudoceratina n. sp.

Type Article
Date 2020-05
Language English
Author(s) Tintillier Florent1, Moriou Céline2, Petek Sylvain1, 3, Fauchon Marilyne3, Hellio Claire3, Saulnier Denis4, Ekins Merrick5, Hooper John N. A.5, Al-Mourabit Ali2, Debitus Cecile1, 3
Affiliation(s) 1 : IRD, Université de la Polynésie française, Ifremer, ILM, EIO, Papeete F-98713, French Polynesia
2 : Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, 91190 Gif-sur-Yvette, France
3 : IRD, Univ Brest, CNRS, Ifremer, LEMAR, F-29280 Plouzane, France
4 : Ifremer, IRD, ILM, Université de la Polynésie française, EIO, Taravao F-98719, French Polynesia
5 : Queensland Museum, PO Box 3300, South Brisbane BC, Queensland 4101, Australia
Source Marine Drugs (1660-3397) (MDPI AG), 2020-05 , Vol. 18 , N. 5 , P. 272 (17p.)
DOI 10.3390/md18050272
WOS© Times Cited 3
Note This article belongs to the Special Issue Marine Natural Product of the South Pacific Area
Keyword(s) sponge, Pseudoceratina, quorum sensing inhibitory activity, antifouling, Verongiida, bromotyrosine
Abstract

Four new brominated tyrosine metabolites, aplyzanzines C–F (1–4), were isolated from the French Polynesian sponge Pseudoceratina n. sp., along with the two known 2-aminoimidazolic derivatives, purealidin A (5) and 6, previously isolated, respectively, from the sponges Psammaplysilla purpurea and Verongula sp. Their structures were assigned based on the interpretation of their NMR and HRMS data. The compounds exhibited quorum sensing inhibition (QSi) and antifouling activities against several strains of bacteria and microalgae. To our knowledge, the QSi activity of this type of bromotyrosine metabolite is described here for the first time.

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Tintillier Florent, Moriou Céline, Petek Sylvain, Fauchon Marilyne, Hellio Claire, Saulnier Denis, Ekins Merrick, Hooper John N. A., Al-Mourabit Ali, Debitus Cecile (2020). Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge Pseudoceratina n. sp. Marine Drugs, 18(5), 272 (17p.). Publisher's official version : https://doi.org/10.3390/md18050272 , Open Access version : https://archimer.ifremer.fr/doc/00630/74200/