Prevalence of Plasmodium spp. in the Amazonian Border Context (French Guiana-Brazil): Associated Factors and Spatial Distribution

Type Article
Date 2020-01
Language English
Author(s) Mosnier Emilie1, 2, Roux EmmanuelORCID3, 4, Cropet Claire5, Lazrek Yassamine6, Moriceau Olivier6, Gaillet Melanie1, Mathieu Luana6, Nacher Mathieu5, Demar Magalie7, Odonne Guillaume8, Douine Maylis2, 5, Michaud Celine1, Pelleau Stephane6, Djossou Felix9, Musset Lise6
Affiliation(s) 1 : Ctr Hosp Andree Rosemon, Pole Ctr Delocalises Prevent & Soins, Ave Flamboyants, F-97306 Cayenne, France.
2 : Univ Guyane, EA3593, Ecosyst Amazoniens & Pathol Trop, Cayenne, France.
3 : Univ Montpellier, Univ Antilles, Univ Guyane, Univ La Reunion,IRD,ESPACE DEV, Montpellier, France.
4 : Fiocruz MS, ICICT, LIS, Rio De Janeiro, Brazil.
5 : Ctr Invest Clin Antilles Guyane, Inserm 1424, Cayenne, France.
6 : Inst Pasteur Guyane, WHO Collaborating Ctr Surveillance Antimalarial D, Ctr Natl Reference Paludisme, Lab Parasitol,Pole Zones Endem, Cayenne, France.
7 : Ctr Hosp Andree Rosemon, Lab Parasitol & Mycol, Cayenne, France.
8 : CNRS, UMSR, Lab Ecol Evolut Interact Syst Amazoniens LEESIA, Cayenne, France.
9 : Ctr Hosp Andree Rosemon, Unite Malad Infect & Trop, Cayenne, France.
Source American Journal Of Tropical Medicine And Hygiene (0002-9637) (Amer Soc Trop Med & Hygiene), 2020-01 , Vol. 102 , N. 1 , P. 130-141
DOI 10.4269/ajtmh.19-0378
WOS© Times Cited 3
Abstract To implement future malaria elimination strategies in French Guiana, a characterization of the infectious reservoir is recommended. A cross-sectional survey was conducted between October and December 2017 in the French Guianese municipality of St Georges de l'Oyapock, located along the Brazilian border. The prevalence of Plasmodium spp. was determined using a rapid diagnostic test (RDT) and a polymerase chain reaction (PCR). Demographic, house locations, medical history, and biological data were analyzed. Factors associated with Plasmodium spp. carriage were analyzed using logistic regression, and the carriage localization was investigated through spatial cluster analysis. Of the 1,501 samples analyzed with PCR, positive results totaled 90 and 10 for Plasmodium vivax and Plasmodium falciparum, respectively. The general PCR prevalence was 6.6% [5.3-7.9], among which 74% were asymptomatic. Only 13/1,549 were positive by RDT. In multivariate analysis, participants older than 15 years, living in a remote neighborhood, with a prior history of malaria, anemia, and thrombocytopenia were associated with an increased odds of Plasmodium spp. carriage. High-risk clusters of P. vivax carriage were detected in the most remote neighborhoods on the village outskirts and two small foci in the village center. We also detected a hot spot for both P. vivax and P. falciparum symptomatic carriers in the northwestern part of the village. The present study confirms a wide-scale presence of asymptomatic P. falciparum and P. vivax carriers in this area. Although they were more often located in remote areas, their geographic distribution was spatially heterogeneous and complex.
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Mosnier Emilie, Roux Emmanuel, Cropet Claire, Lazrek Yassamine, Moriceau Olivier, Gaillet Melanie, Mathieu Luana, Nacher Mathieu, Demar Magalie, Odonne Guillaume, Douine Maylis, Michaud Celine, Pelleau Stephane, Djossou Felix, Musset Lise (2020). Prevalence of Plasmodium spp. in the Amazonian Border Context (French Guiana-Brazil): Associated Factors and Spatial Distribution. American Journal Of Tropical Medicine And Hygiene, 102(1), 130-141. Publisher's official version : https://doi.org/10.4269/ajtmh.19-0378 , Open Access version : https://archimer.ifremer.fr/doc/00657/76880/