Chemotaxonomy and cytotoxicity of the liverwort Porella Viridissima
| Type | Article | ||||||||||||
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| Acceptance Date | 2019-08 IN PRESS | ||||||||||||
| Language | English | ||||||||||||
| Author(s) | Métoyer Benjamin1, 2, Lebouvier Nicolas1, Hnawia Edouard1, Thouvenot Louis3, Wang Fengrui4, Harinantenaina Rakotondraibe Liva4, Raharivelomanana Phila5, Asakawa Yoshinori2, Nour Mohammed1 | ||||||||||||
| Affiliation(s) | 1 : Institut des Sciences Exactes et Appliquées (ISEA)-EA 4243, Université de la Nouvelle-Calédonie, Nouméa Cedex, Nouvelle-Calédonie, France 2 : Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan 3 : Independant Researcher, Pergignan, France 4 : Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA 5 : Ecosystèmes Insulaires Océaniens (UMR EIO 241), University of French Polynesia, Faaa, French Polynesia |
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| Source | Natural Product Research (1478-6419) (Informa UK Limited) In Press | ||||||||||||
| DOI | 10.1080/14786419.2019.1655022 | ||||||||||||
| Keyword(s) | Liverwort, Porella viridissima, chemotype, pinguisane, sacculatane, ovarian cancer | ||||||||||||
| Abstract | The first chemotaxonomic study based on volatile components of Porella viridissima (Mitt.) Grolle is reported. The GC-MS analysis of ether extract was performed; ten santalane and five pinguisane-type sesquiterpenes were identified together with perrottetianal A as major diterpene. Most of detected santalane-type sesquiterpenes are reported for the first time in liverwort. P. viridissima was found to belong to the chemotype III (pinguisane/sacculatane) and shared chemical similarities with P. navicularis. Perrotettianal A was isolated and has shown strong cytotoxicity against ovarian cancer. |
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