Chemotaxonomy and cytotoxicity of the liverwort Porella Viridissima

Type Article
Date 2021
Language English
Author(s) Métoyer Benjamin1, 2, Lebouvier Nicolas1, Hnawia Edouard1, Thouvenot Louis3, Wang Fengrui4, Harinantenaina Rakotondraibe Liva4, Raharivelomanana Phila5, Asakawa Yoshinori2, Nour Mohammed1
Affiliation(s) 1 : Institut des Sciences Exactes et Appliquées (ISEA)-EA 4243, Université de la Nouvelle-Calédonie, Nouméa Cedex, Nouvelle-Calédonie, France
2 : Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan
3 : Independant Researcher, Pergignan, France
4 : Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA
5 : Ecosystèmes Insulaires Océaniens (UMR EIO 241), University of French Polynesia, Faaa, French Polynesia
Source Natural Product Research (1478-6419) (Informa UK Limited), 2021 , Vol. 35 , N. 12 , P. 2099-2102
DOI 10.1080/14786419.2019.1655022
Keyword(s) Liverwort, Porella viridissima, chemotype, pinguisane, sacculatane, ovarian cancer
Abstract

The first chemotaxonomic study based on volatile components of Porella viridissima (Mitt.) Grolle is reported. The GC-MS analysis of ether extract was performed; ten santalane and five pinguisane-type sesquiterpenes were identified together with perrottetianal A as major diterpene. Most of detected santalane-type sesquiterpenes are reported for the first time in liverwort. P. viridissima was found to belong to the chemotype III (pinguisane/sacculatane) and shared chemical similarities with P. navicularis. Perrotettianal A was isolated and has shown strong cytotoxicity against ovarian cancer.

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Métoyer Benjamin, Lebouvier Nicolas, Hnawia Edouard, Thouvenot Louis, Wang Fengrui, Harinantenaina Rakotondraibe Liva, Raharivelomanana Phila, Asakawa Yoshinori, Nour Mohammed (2021). Chemotaxonomy and cytotoxicity of the liverwort Porella Viridissima. Natural Product Research, 35(12), 2099-2102. Publisher's official version : https://doi.org/10.1080/14786419.2019.1655022 , Open Access version : https://archimer.ifremer.fr/doc/00660/77195/