Improving the Antioxidant Properties of Calophyllum inophyllum Seed Oil from French Polynesia: Development and Biological Applications of Resinous Ethanol-Soluble Extracts

Type Article
Date 2021-02
Language English
Author(s) Cassien Mathieu1, 2, 3, Mercier Anne1, Thétiot-Laurent SophieORCID1, Culcasi Marcel1, Ricquebourg EmilieORCID1, Asteian Alice1, Herbette GaëtanORCID4, Bianchini Jean-Pierre2, Raharivelomanana Phila2, Pietri Sylvia1
Affiliation(s) 1 : Campus Saint-Jérôme, CNRS, ICR, UMR 7273, SMBSO, Aix Marseille Université, 13397 Marseille, France
2 : IFREMER, ILM, IRD, EIO UMR 241, Université Polynésie Française, 98702 Faa’a Tahiti, French Polynesia
3 : Yelen Analytics, 13820 Ensuès–la-Redonne, France
4 : CNRS, Spectropole FSCM, Aix Marseille Université, 13397 Marseille, France
Source Antioxidants (2076-3921) (MDPI AG), 2021-02 , Vol. 10 , N. 2 , P. 199 (23p.)
DOI 10.3390/antiox10020199
Keyword(s) Calophyllum inophyllum L., Tamanu oil, ethanol-soluble resin extracts, lipophilic antioxidants, phenolics, pyranocoumarins, antimicrobial, anti-inflammatory, UV protection, EPR spin trapping
Abstract

Tamanu oil from Calophyllum inophyllum L. has long been used in traditional medicine. Ethanol extraction was found the best strategy for recovering bioactive compounds from the resin part of Tamanu oil, yielding two neutral and acidic resins fractions with high phenolics, flavonoids and pyranocoumarins concentrations. A further cascade of LPLC/HPLC separations of neutral and acidic resin fractions allowed identifying fifteen metabolites, and among them, calanolide D and 12-oxocalanolide A (both in neutral fraction) were first identified from a natural source. All these extracts, subfractions and isolated metabolites demonstrated increased free radical scavenging, antioxidant, anti-inflammatory, antimicrobial and antimycobacterial activity compared to Tamanu oil and its de-resinated lipid phase. Overall, these results could promote resinous ethanol-soluble Tamanu oil extracts as a useful multifaceted and renewable medicinal resource

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Cassien Mathieu, Mercier Anne, Thétiot-Laurent Sophie, Culcasi Marcel, Ricquebourg Emilie, Asteian Alice, Herbette Gaëtan, Bianchini Jean-Pierre, Raharivelomanana Phila, Pietri Sylvia (2021). Improving the Antioxidant Properties of Calophyllum inophyllum Seed Oil from French Polynesia: Development and Biological Applications of Resinous Ethanol-Soluble Extracts. Antioxidants, 10(2), 199 (23p.). Publisher's official version : https://doi.org/10.3390/antiox10020199 , Open Access version : https://archimer.ifremer.fr/doc/00677/78918/