Diverging patterns of introgression from Schistosoma bovis across S. haematobium African lineages

Type Article
Date 2021-02
Language English
Author(s) Rey OlivierORCID1, Toulza EveORCID1, Chaparro CristianORCID1, Allienne Jean-François1, Kincaid-Smith Julien1, 2, Mathieu-Begné EglantineORCID1, Allan Fiona3, Rollinson DavidORCID3, Webster Bonnie L.ORCID3, Boissier JérômeORCID1
Affiliation(s) 1 : Univ. Montpellier, CNRS, IFREMER, UPVD, IHPE, Perpignan, France
2 : Centre for Emerging, Endemic and Exotic Diseases (CEEED), Department of Pathobiology and Population Sciences (PPS), Royal Veterinary College, University of London, Hawkshead Campus, Herts, United Kingdom
3 : Wolfson Wellcome Biomedical Laboratories, Department of Life Sciences, Natural History Museum, London, United Kingdom, London Centre for Neglected Tropical Disease Research, Imperial College London School of Public Health, London, United Kingdom
Source PLOS Pathogens (1553-7374) (Public Library of Science (PLoS)), 2021-02 , Vol. 17 , N. 2 , P. 1009313 (20p.)
DOI 10.1371/journal.ppat.1009313
Abstract

Hybridization is a fascinating evolutionary phenomenon that raises the question of how species maintain their integrity. Inter-species hybridization occurs between certain Schistosoma species that can cause important public health and veterinary issues. In particular hybrids between Schistosoma haematobium and S. bovis associated with humans and animals respectively are frequently identified in Africa. Recent genomic evidence indicates that some S. haematobium populations show signatures of genomic introgression from S. bovis. Here, we conducted a genomic comparative study and investigated the genomic relationships between S. haematobium, S. bovis and their hybrids using 19 isolates originating from a wide geographical range over Africa, including samples initially classified as S. haematobium (n = 11), S. bovis (n = 6) and S. haematobium x S. bovis hybrids (n = 2). Based on a whole genomic sequencing approach, we developed 56,181 SNPs that allowed a clear differentiation of S. bovis isolates from a genomic cluster including all S. haematobium isolates and a natural S. haematobium-bovis hybrid. All the isolates from the S. haematobium cluster except the isolate from Madagascar harbored signatures of genomic introgression from S. bovis. Isolates from Corsica, Mali and Egypt harbored the S. bovis-like Invadolysin gene, an introgressed tract that has been previously detected in some introgressed S. haematobium populations from Niger. Together our results highlight the fact that introgression from S. bovis is widespread across S. haematobium and that the observed introgression is unidirectional.

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Publisher's official version 20 1 MB Open access
S1 Table. Sequencing and alignment statistics obtained for each isolate analysed in this study. 10 KB Open access
S2 Table. Details of the 29 genomic tracts that display a significant decrease in genomic divergence between either at least one S. haematobium isolate and all S. bovis isolates or at least one S. bov 13 KB Open access
S1 Fig. Plots obtained from a PCA analysis based on 56.141 SNPs developed from the initial alignment of sequencing reads on the S. haematobium genome of reference. Isolates are projected within... 1 758 KB Open access
S2 Fig. Plots obtained from a PCA analysis based on 172.046 SNPs developed from the initial alignment of sequencing reads on the S. bovis genome of reference. Isolates are projected ... 1 801 KB Open access
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How to cite 

Rey Olivier, Toulza Eve, Chaparro Cristian, Allienne Jean-François, Kincaid-Smith Julien, Mathieu-Begné Eglantine, Allan Fiona, Rollinson David, Webster Bonnie L., Boissier Jérôme (2021). Diverging patterns of introgression from Schistosoma bovis across S. haematobium African lineages. PLOS Pathogens, 17(2), 1009313 (20p.). Publisher's official version : https://doi.org/10.1371/journal.ppat.1009313 , Open Access version : https://archimer.ifremer.fr/doc/00678/79020/