After a few weeks, underwater components of offshore structures are colonized by marine species and after few years this marine growth can be significant. It has been shown that it affects the hydrodynamic loading of cylinder components such as legs and braces for jackets, risers and mooring lines for floating units. Over a decade, the development of Floating Offshore Wind Turbines highlighted specific effects due to the smaller size of their components. The effect of the roughness of hard marine growth on cylinders with smaller diameter increased and the shape should be representative of a real pattern. This paper first describes the two realistic shapes of a mature colonization by mussels and then presents the tests of these roughnesses in a hydrodynamic tank where three conditions are analyzed: current, wave and current with wave. Results are compared to the literature with a similar roughness and other shapes. The results highlight the fact that, for these realistic roughnesses, the behavior of the rough cylinders is mainly governed by the flow and not by their motions.