Rapid evolutionary turnover of mobile genetic elements drives bacterial resistance to phages
Type | Article | ||||||||||||||||||||
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Date | 2021-10 | ||||||||||||||||||||
Language | English | ||||||||||||||||||||
Author(s) | Hussain Fatima Aysha1, Dubert Javier1, 2, Elsherbini Joseph1, Murphy Mikayla1, Vaninsberghe David1, Arevalo Philip1, Kauffman Kathryn1, Rodino-Janeiro Bruno Kotska1, 3, Gavin Hannah1, Gomez Annika1, Lopatina Anna3, Le Roux Frederique4, 5, Polz Martin F.1, 3 | ||||||||||||||||||||
Affiliation(s) | 1 : Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. 2 : Department of Microbiology and Parasitology, University of Santiago de Compostela, Santiago de Compostela, Spain. 3 : Division of Microbial Ecology, Department of Microbiology and Ecosystem Science, Center for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria. 4 : Ifremer, Unité Physiologie Fonctionnelle des Organismes Marins, CS 10070, F-29280 Plouzané, France. 5 : Sorbonne Universités, UPMC Paris 06, CNRS, UMR 8227, Integrative Biology of Marine Models, Station Biologique de Roscoff, CS 90074, F-29688 Roscoff Cedex, France. |
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Source | Science (0036-8075) (American Association for the Advancement of Science (AAAS)), 2021-10 , Vol. 374 , N. 6566 , P. 488-492 | ||||||||||||||||||||
DOI | 10.1126/science.abb1083 | ||||||||||||||||||||
WOS© Times Cited | 64 | ||||||||||||||||||||
Abstract | Although it is generally accepted that phages drive bacterial evolution, how these dynamics play out in the wild remains poorly understood. We found that susceptibility to viral killing in marine Vibrio is mediated by large and highly diverse mobile genetic elements. These phage defense elements display exceedingly fast evolutionary turnover, resulting in differential phage susceptibility among clonal bacterial strains while phage receptors remain invariant. Protection is cumulative, and a single bacterial genome can harbor 6 to 12 defense elements, accounting for more than 90% of the flexible genome among close relatives. The rapid turnover of these elements decouples phage resistance from other genomic features. Thus, resistance to phages in the wild follows evolutionary trajectories alternative to those predicted from laboratory-based evolutionary experiments. |
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