Deep-Water Fish Are Potential Vectors of Ciguatera Poisoning in the Gambier Islands, French Polynesia

Type Article
Date 2021-11
Language English
Author(s) Darius Hélène TaianaORCID1, Revel Taina1, Cruchet Philippe1, Viallon Jérôme1, Gatti Clémence Mahana ItiORCID1, Sibat ManoellaORCID2, Hess PhilippORCID2, Chinain MireilleORCID1
Affiliation(s) 1 : Institut Louis Malardé (ILM), Laboratory of Marine Biotoxins, UMR 241-EIO (IFREMER, ILM, IRD, University of French Polynesia), P.O. Box 30, 98713 Papeete, Tahiti, French Polynesia
2 : Ifremer, DYNECO, Laboratoire Phycotoxines, F-44000 Nantes, France
Source Marine Drugs (1660-3397) (MDPI AG), 2021-11 , Vol. 19 , N. 11 , P. 644 (24p.)
DOI 10.3390/md19110644
WOS© Times Cited 4
Note This article belongs to the Special Issue Marine Biotoxins
Keyword(s) deep-water fish, ciguatera poisoning, rRBA, MBA, CBA-N2a, <p>LC-MS/MS</p>, composite ciguatoxicity, CTX1B analogs, Gambier Islands
Abstract

Ciguatera poisoning (CP) cases linked to the consumption of deep-water fish occurred in 2003 in the Gambier Islands (French Polynesia). In 2004, on the request of two local fishermen, the presence of ciguatoxins (CTXs) was examined in part of their fish catches, i.e., 22 specimens representing five deep-water fish species. Using the radioactive receptor binding assay (rRBA) and mouse bioassay (MBA), significant CTX levels were detected in seven deep-water specimens in Lutjanidae, Serranidae, and Bramidae families. Following additional purification steps on the remaining liposoluble fractions for 13 of these samples (kept at −20 °C), these latter were reanalyzed in 2018 with improved protocols of the neuroblastoma cell-based assay (CBA-N2a) and liquid chromatography tandem mass spectrometry (LC–MS/MS). Using the CBA-N2a, the highest CTX-like content found in a specimen of Eumegistus illustris (Bramidae) was 2.94 ± 0.27 µg CTX1B eq. kg−1. Its toxin profile consisted of 52-epi-54-deoxyCTX1B, CTX1B, and 54-deoxyCTX1B, as assessed by LC–MS/MS. This is the first study demonstrating that deep-water fish are potential ciguatera vectors and highlighting the importance of a systematic monitoring of CTXs in all exploited fish species, especially in ciguatera hotspots, including deep-water fish, which constitute a significant portion of the commercial deep-sea fisheries in many Asian–Pacific countries

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How to cite 

Darius Hélène Taiana, Revel Taina, Cruchet Philippe, Viallon Jérôme, Gatti Clémence Mahana Iti, Sibat Manoella, Hess Philipp, Chinain Mireille (2021). Deep-Water Fish Are Potential Vectors of Ciguatera Poisoning in the Gambier Islands, French Polynesia. Marine Drugs, 19(11), 644 (24p.). Publisher's official version : https://doi.org/10.3390/md19110644 , Open Access version : https://archimer.ifremer.fr/doc/00735/84728/