Sulfo-Gambierones, Two New Analogs of Gambierone Produced by Gambierdiscus excentricus

Type Article
Date 2021-12
Language English
Author(s) Yon Thomas1, Sibat ManoellaORCID1, Robert Elise1, Lhaute Korian1, Holland Wiliam C2, Litaker R Wayne3, Bertrand Samuel4, 5, Hess PhilippORCID1, Reveillon DamienORCID1
Affiliation(s) 1 : Laboratoire Phycotoxines, DYNECO, Ifremer, F-44000 Nantes, France
2 : Beaufort Laboratory, National Centers for Coastal Ocean Science, National Ocean Service, NOAA, Beaufort, NC 28516, USA
3 : CSS, Inc. Under Contract to National Oceanic and Atmospheric Administration, National Centers for Coastal Ocean Science, National Ocean Service, Beaufort, NC 28516, USA
4 : Institut des Substances et Organismes de la Mer, ISOMER, Nantes Université, UR 2160, F-44000 Nantes, France
5 : ThalassOMICS Metabolomics Facility, Plateforme Corsaire, Biogenouest, 44311 Nantes, France
Source Marine Drugs (1660-3397) (MDPI AG), 2021-12 , Vol. 19 , N. 12 , P. 657 (19p.)
DOI 10.3390/md19120657
WOS© Times Cited 5
Note This article belongs to the Special Issue Marine Biotoxins
Keyword(s) Gambierdiscus excentricus, sulfo-gambierones, high-resolution mass spectrometry, Neuro2a cell-based assay
Abstract

Ciguatera poisoning is caused by the ingestion of fish or shellfish contaminated with ciguatoxins produced by dinoflagellate species belonging to the genera Gambierdiscus and Fukuyoa. Unlike in the Pacific region, the species producing ciguatoxins in the Atlantic Ocean have yet to be definitely identified, though some ciguatoxins responsible for ciguatera have been reported from fish. Previous studies investigating the ciguatoxin-like toxicity of Atlantic Gambierdiscus species using Neuro2a cell-based assay identified G. excentricus as a potential toxin producer. To more rigorously characterize the toxin profile produced by this species, a purified extract from 124 million cells was prepared and partial characterization by high-resolution mass spectrometry was performed. The analysis revealed two new analogs of the polyether gambierone: sulfo-gambierone and dihydro-sulfo-gambierone. Algal ciguatoxins were not identified. The very low ciguatoxin-like toxicity of the two new analogs obtained by the Neuro2a cell-based assay suggests they are not responsible for the relatively high toxicity previously observed when using fractionated G. excentricus extracts, and are unlikely the cause of ciguatera in the region. These compounds, however, can be useful as biomarkers of the presence of G. excentricus due to their sensitive detection by mass spectrometry

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How to cite 

Yon Thomas, Sibat Manoella, Robert Elise, Lhaute Korian, Holland Wiliam C, Litaker R Wayne, Bertrand Samuel, Hess Philipp, Reveillon Damien (2021). Sulfo-Gambierones, Two New Analogs of Gambierone Produced by Gambierdiscus excentricus. Marine Drugs, 19(12), 657 (19p.). Publisher's official version : https://doi.org/10.3390/md19120657 , Open Access version : https://archimer.ifremer.fr/doc/00735/84732/