Plastic and microplastic pollutions are known to be widespread across the planet in all types of environments. However, relatively little about microplastic quantities in the deeper areas of the oceans is known, due to the difficulty to reach these environments. In this work, we present an investigation of microplastic (<5 mm) distribution performed in the bottom sediments of the abyssal plain off the coast and the canyon of Toulon (France). Four samples of deep-sea sediment were collected at the depth of 2443 m during the sea operations carried out by the French oceanographic cruises for the KM3NeT project. The chemical and physical characterisation of the sediment was carried out, and items were extracted from sediments by density separation and analysed by optical microscope and µRaman spectroscopy. Results show microplastics in the deep-sea sediments with a concentration of about 80 particles L−1, confirming the hypothesis of microplastics spread to abyssal sediments in the Mediterranean Sea.